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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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小剂量吉西他滨可促进放疗致人肝癌细胞株smmc-7721的凋亡
, PP. 301-304
Keywords: 放射肿瘤学,肝肿瘤/放射疗法,放射敏感性/药物作用,细胞凋亡/药物作用,smmc-7721细胞株,吉西他滨
Abstract:
目的观察小剂量吉西他滨(gem)对放疗诱导的人肝癌细胞株smmc-7721凋亡的促进作用。方法将体外培养的人肝癌细胞株smmc-7721分为空白对照、单纯放疗、单纯化疗及放疗加化疗4组,应用mtt法检测不同条件下smmcc-7721细胞的生长活性;经光学显微镜、透射电镜及荧光显微镜观察各组细胞经gem作用后凋亡的形态学变化。结果单纯放、化疗都可诱导gem细胞凋亡,gem可明显增加放疗诱导的细胞凋亡。结论小剂量gem可明显增加放疗诱导的smmc-7721细胞的凋亡。
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