|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
腺苷a1受体对新生鼠离体延髓脑片呼吸节律性放电的影响
, PP. 277-280
Keywords: 腺苷a1受体,面神经后核内侧区,呼吸节律,节律性放电
Abstract:
目的探讨腺苷a1受体在基本呼吸节律产生和调节中的可能作用。方法制作新生大鼠离体延髓脑片标本,主要包含面神经后核内侧区(themedialregionofthenucleusretrofacialis,mnrf),并保留舌下神经根的完整,以改良kreb’s液灌流脑片,稳定记录舌下神经根呼吸节律性放电(respiratoryrhythmicaldischargeactivity,rrda)。在灌流液中先分别单独给予腺苷a1受体的特异性拮抗剂8-环戊-1,3-二丙基黄嘌呤(8-cyclopentyl-1,3-dipropylxanthine,dpcpx)和特异性激动剂r-苯异丙基-腺苷(r-phenylisoprpyl-adenosine,r-pia);再分别先后给予r-pia和r-pia+dpcpx,观察rrda的变化,进一步探讨腺苷a1受体对其的调节作用。结果给予腺苷a1受体拮抗剂dpcpx后,呼气时程和呼吸周期明显缩短,吸气时程和积分幅度未出现显著性变化;给予腺苷a1受体激动剂r-pia后,吸气时程,积分幅度显著性降低,呼吸周期和呼气时程明显延长,且r-pia的呼吸抑制作用可部分被dpcpx逆转。结论腺苷a1受体参于了哺乳动物基本呼吸节律的产生和调节中起着重要的作用。
| [1] | 吴中海,张枫桐,李有仁.家兔面神经后核内侧在呼吸节律起源中的作用[j].生理学报,1990,42(1):68-75.wuzh,zhangft,liyr.roleofthemedialregionofnucleusretrofacialisoftherabbitinthegenerationofrespiratoryrhythm[j].actaphysiolsin,1990,42(1):68-75.
|
| [2] | 吴中海,张枫桐,李有仁.阻滞面神经后核内侧区对节律性呼吸的影响[j].第一军医大学学报,1994,14(1):9-11.wuzh,zhangft,liyr.effectofblockingmedialareaofnucleusretrofacialisonrespiratoryrhythm[j].jfirstmilmeduniv/diyijunyidaxuexuebao,1994,14(1):9-11.
|
| [3] | 吴中海,胡德辉,高扬.新生大鼠离体延髓脊髓标本的呼吸节律性放电及微切割延髓对其放电的影响[j].第一军医大学学报,1998,18(4):260-2.wuzh,hudh,gaoy.respiratoryrhythmicaldischargeactivityofmedulla-spinalpreparationisolatedfrommewbomratandeffectofmicrosectionofmedullaontheactivity[j].jfirstmilmeduniv/diyijunyidaxuexuebao,1998,18(4):260-2.
|
| [4] | mynlieffm,beamkg.adenosineactingatana1receptordecreasesn-typecalciumcurrentinmousemotoneurons[j].neuroscience,1994,14(6):3628-34.
|
| [5] | katchmanan,hershkowitzn.adenosineantagonistspreventhypoxiainduceddepressionofexcitatorybutnotinhibitorysynapticcurrents[j].neuroscienceletters,1993,159(1-2):123-6.
|
| [6] | herleniuse,lagercrantah.adenosinergicmodulationofrespiratoryneuronesintheneonatalratbrainsteminvitro[j].physiol,1999,518(1):159-72.
|
| [7] | dongxw,feldmanjl.modulationofinspiratorydrivetophrenicmotoneuronsbypresynapticadenosinea1receptors[j].neurosci,1995,15(5):3458-67.
|
| [8] | erich,ulrikaa,lieqt.perinatalrespiratorycontrolanditsmodulationbyadenosineandcaffeineinthera[j].pediatrres,2002,51(1):4-12.
|
| [9] | greenerw,haashl.theelectrophysiologyofadenosineinthemammaliancentralnervoussystem[j].progneurobiol,1991,36(4):329-41.
|
| [10] | scholzkp,millerrj.analysisofadenosineactionsonca2[17]trusselllo,jacksonmb.dependenceofanadenosine-activatedpotassiumcurrentonagtp-bindingproteininmammaliancentralneurons[j].neurosci,1987,7(10):3306-16.
|
| [11] | shaoxm,geq,feldmanjl.modulationofampareceptorsbycamp-dependentproteinkinaseinprebotzingercomplexinspiratoryneuronsregulatesrespiratoryrhythmintherat[j].physiol,2003,547(2):543-53.
|
| [12] | onimaruh,arataa,hommai.primaryrespiratoryrhythmgenerationinthemedullaofbrainstem-spinalcordpreparationfromnewbornrat[j].brainres,1988,445(2):314-24.
|
| [13] | smithjc,ellenbergerh,ballanyik,etal.pre-b?tzingercomplex:abrainstemregionthatmaygeneraterespiratoryrhythminmammals[j].science,1991,254(5032):726-29.
|
| [14] | zhangft,wuzh,liyr.effectofblockingmedialareaofnucleusretrofacialisonrespiratoryrhythm[j].respirphysiol,1991,85(1):73-81.
|
| [15] | hilaireg,bouc,monteaur.rostralventrolateralmedullaandrespiratoryrhythmgenesisinmice[j].neuroscilett,1997,224(1):13-6.
|
| [16] | 吴中海,张枫桐,徐小元.损毁面神经后核内侧区神经元细胞对呼吸节律的影响[j].第一军医大学学报,1992,12(3):223-7.wuzh,zhangft,xuxy.effectsofchemicaldestructionofthemedialregionofnucleusretrofacialisinrespiratoryrhythm[j].jfirstmilmeduniv/diyijunyidaxuexuebao,1992,12(3):223-7.
|
| [17] | suzuet.respiratoryrhythmgenerationintheinvitrobrainstem-spinalcordpreparationoftheneonatalrat[j].jphysiol,1984,354:173-83.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
