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OALib Journal期刊
ISSN: 2333-9721
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糖基化终极产物对乳鼠心肌细胞胞内游离钙瞬间变化的影响
Keywords: 糖基化终极产物,心肌细胞,游离钙,细胞内,激光共聚焦显微镜
Abstract:
目的探讨糖基化终极产物(ages)刺激对体外培养乳鼠心肌细胞内游离钙的影响。方法应用荧光钙离子指示剂fluo-3/am将体外培养3~5d的乳鼠心肌细胞染色,激光共聚焦显微镜(lscm)观察不同浓度ages(50、100、200μg/ml)对心肌细胞瞬时刺激后细胞内游离钙离子浓度的影响。结果与对照组相比,ages刺激可以迅速引起心肌细胞胞内游离钙浓度的升高,其恢复时程显著延长并呈剂量依赖性。结论ages可能通过改变心肌细胞内游离钙离子浓度对心肌细胞造成损伤。
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