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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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广东汉族人群hla-cw多态性及单体型分析
, PP. 900-903
Keywords: 人类白细胞抗原-cw,单体型,基因频率,多态性
Abstract:
目的检测广东汉族人群hla-cw及hla-a、b、drb1基因频率,分析该人群hla-cw等位基因多态性及其单体型特点。方法骨髓移植供者185例,抗凝血提取dna,半量全自动pcr-rsso分型检测hla-a、b、cw、drb1基因型。结果在分辨水平检出cw等位基因11个,其中分布频率较高的依次为cw*03(0.2580)、cw*07(0.1887)、cw*01(0.1732)、cw*08(0.1070)。统计分析呈现显著连锁不平衡的hla-cw-a单体型7个,hla-cw-b单体型20个,hla-cw-drb1单体型10个。结论广东汉族群体hla-cw基因具有较为丰富的多态性,其与hla-a、b、drb1间连锁不平衡单体型具有地区性遗传特征。
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