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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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同期放化疗治疗中晚期鼻咽癌临床研究
, PP. 694-696
Keywords: 鼻咽肿瘤/放射疗法,鼻咽肿瘤/药物疗法,叶酸,氟尿嘧啶,顺铂,抗肿瘤药,多剂联用
Abstract:
目的观察及评价同期放化疗治疗中晚期鼻咽癌(ⅲ或ⅳa期)的疗效。方法80例确诊为ⅲ、ⅳa期的中晚期鼻咽癌患者随机分为同期放化疗组(a组)和单纯放疗组(b组),每组40例。a组给予甲酰四氢叶酸+5-氟脲嘧啶+顺铂联合化疗,4周后给予第二程化疗;b组只给单纯放射治疗。两组放疗方法相同,为常规分割剂量,鼻咽放疗剂量为66~76gy/6.6~7.6周,颈淋巴结放疗剂量为60~72gy/6.0~7.2周。结果所有病人均顺利完成既定治疗方案。a组同b组治疗结束时鼻咽原发灶和颈淋巴结消退率分别是77.5%vs60.0%(p>0.05)和92.5%vs70.0%(p<0.05);治疗后3个月,两组鼻咽原发灶和颈淋巴结消退率分别为92.5%vs72.5%(p<0.05)和100%vs85.0%(p<0.05)。毒副作用:a组胃肠道反应、骨髓毒性高于b组(p<0.01);两组口腔粘膜及皮肤反应程度相当。结论同期放化疗可以提高中晚期(ⅲ或ⅳa期)鼻咽癌患者的肿瘤消退率,其毒性反应可以耐受,不影响放疗的顺利完成。放疗前诱导化疗能缩短治疗时间,是鼻咽癌综合治疗的可行性方法。
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