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OALib Journal期刊
ISSN: 2333-9721
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经皮腔内冠脉介入术对冠脉循环中肾上腺髓质素及肿瘤坏死因子的影响
Keywords: 肾上腺髓质素,肿瘤坏死因子,经皮腔内冠脉介入术,球囊扩张,支架置入,冠脉循环
Abstract:
目的探讨经皮腔内冠脉介入术对冠脉循环中肾上腺髓质素(adm)及肿瘤坏死因子α(tnf-α)水平的影响。方法33例冠心病患者分别于冠脉造影前后即刻、球囊扩张(ptca)后即刻、支架置入后即刻、术后10min采集冠状静脉窦血,同时采集股动脉血,采用放免法测定adm、tnf-α浓度。结果冠脉造影前后adm及tnf-α无明显变化(p>0.05);ptca后即刻冠状窦内adm和tnf-α明显升高(p<0.01);支架后即刻adm有上升趋势(p>0.05);术后10minadm降至术前水平。结论冠脉造影对冠脉循环血管活性物质基本不影响;ptca及支架术后冠脉循环中adm和tnf-α升高,可能与球囊损伤内皮、支架对管壁的机械压迫及刺激有关,两者可能参与了ptca及支架术后急性闭塞、再狭窄的调节。
| [1] | kitamurak,kangawak,kawamotom,etal.adrenomedullin:anovelhypotensivepeptideisolatedfromhumanpheochromocytoma[j].biochembiophysrescommun,1993,192(2):553-60.
|
| [2] | tianq,zhaod,tandy,etal.hypotensiveeffectsandmechanismsofadrenomedullin(13-52)[j].chinjhypertens,1994,2:13
|
| [3] | kanoh,kohnom,yasunarik,etal.adrenomedullinasanovelantiproliferativefactorofvascularsmoothmusclecells[j].jhypertens,1996,14(2):209-13.
|
| [4] | horiot,kanoh,yoshiharaf,etal.adrenomedullinasanovelantimigrationfactorofvascularsmoothmusclecells[j].circres,1995,77(4):660-4.
|
| [5] | agataj,zhangjj,chaoj,etal.adrenomedullingenedeliveryinhibitsneointimaformationinrtaarteryafterballoonangioplasty[j].regulpept,2003,112(1-3):115-20.
|
| [6] | 刘乃奎,陈光慧,王晓红,等.血管活性肽在大鼠血管再狭窄形成中的作用[j].中华医学杂志,2001,81(3):162-7.liunk,chengh,wangxh,etal.effectsofvasoactivepeptidesonthedevelopmentofrestenosis[j].natlmedjchin,2001,81(3):162-7.
|
| [7] | isumiy,shojih,sugos,etal.regulationofadrenomedullinproductioninratendothelialcells[j].endocrinology,1998,139(3):838-46.
|
| [8] | kemalem,geney,kiziltunea,etal.increasedplasmaadrenomedullininpatientsundergoingpercutaneoustransluminalcoronaryangioplasty[j].swissmedwkly,2001,131(3-4):50-3.
|
| [9] | hofbauerkh,jensenbl,kurtza,etal.tissuehypoxygenationactivatestheadrenomedullinsysteminvivo[j].amjphysiolregulintegrcompphysiol,2000,278(2):r513-9.
|
| [10] | nakayamam,takahashik,murakamio,etal.inductionofadrenomedullinbyhypoxiainculturedhumancoronaryarteryendothelialcells[j].peptides,1999,20(6):769-72.
|
| [11] | yoshitomiy,nisbikimit,kojimas,etal.plasmalevelsofadrenomedullininpatientswithacutemyocardialinfarction[j].clinsci,1998,94(2):135-9.
|
| [12] | horiot,nisbikimit,yoshiharaf,etal.productionandsecretionofadrenomedullininculturedratcardiacmyocytesandnoumyocytes:stimutationbyil-1βandtnf-α[j].endocrinology,1998,139(11):4576-80.
|
| [13] | coppockha,owjiaa,austinc,etal.rat-2fibroblastsexpressspecificadrenomedullinreceptors,butnotcalcitonin-gene-relatedpeptidereceptors,whichmediateincreasedintracellularcampandinhibitmitogen-activatedproteinkinaseactivity[j].biochemj,1999,338(pt1):15-22.
|
| [14] | barkers,leesdm,woodeg,etal.inhibitoryeffectofadrenomedullinonbasalandtumour,necrosisfactoralpha-stimulatedendothelin-1synthesisinbovineaorticendothelialcellsisindependentofcyclicamp[j].biochempharmacol,2002,63(2):149-56.
|
| [15] | lang-rollini,schurekjo,langre,etal.platelet-inducedinhibitionofadrenomedullinsecretion[j].eurjpharmacol,2001,427(2):115-8.
|
| [16] | 孙宁玲,王伟民,李明,等.冠状动脉成形术对冠心病合并高血压患者血浆肾上腺髓质素和内皮素的影响[j].中华心血管病杂志,2001,29(4):210-2.sunnl,wangwm,lim,etal.achangeofadrenomeduliumandendothlin-1inpatientswithhypertensionandcoronaryarterylesion[j].chinjcardiol,2001,29(4):210-2.
|
| [17] | 曹静,张钧华,王晓红,等.肾上腺髓质素在心肌缺血再灌注病人血浆中的变化及其对心肌的保护作用[j].中华医学杂志,2000,80(4):261-4.caoj,zhangjh,wangxh,etal.changesandcardiacprotectiveeffectsofadrenomedullinduringmyocardialischemia-reperfusionperiod[j].natlmedjchin,2000,80(4):261-4.
|
| [18] | sugos,minaminon,shojih,etal.interleukin-1,tumornecrosisfactorandlipopolysaccharideadditivelystimulateproductionofadrenomedullininvascularsmoothmusclecells[j].biochembiophysrescommun,1995,207(1):25-32.
|
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