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OALib Journal期刊
ISSN: 2333-9721
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食管癌组织中hmsh2基因的表达
Keywords: 食管肿瘤,dna错配修复基因,hmsh2
Abstract:
目的观察食管癌组织中dna错配修复基因hmsh2的表达。方法32例食管癌患者术前均未接受放疗、化疗等其他治疗,标本切除后0.5h内在癌灶、癌旁及正常残端各取1cm×1cm×1cm大小的组织块,应用原位杂交法检测hmsh2。结果食管癌组织中hmsh2的阳性表达率为46.88%、癌旁为53.12%、正常组织为84.38%。与正常食管组织相比,食管癌和癌旁组织中hmsh2的阳性表达率均明显降低(p<0.05)。hmsh2阳性表达率与食管癌患者年龄及性别,肿瘤大小、肿瘤位置、病理类型、组织学分级、淋巴结转移、浸润深度等均无明显相关性(p>0.05)。结论hmsh2缺失是食管癌发生的早期事件。
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