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OALib Journal期刊
ISSN: 2333-9721
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对氧磷酶1基因gln192arg多态性与阿尔茨海默病的关联研究
, PP. 371-374
Keywords: 对氧磷酶1,载脂蛋白e,阿尔茨海默病,限制性片段长度多态性
Abstract:
目的探讨对氧磷酶1(paraoxonase-1,pon1)基因gln192arg多态性与汉族散发阿尔茨海默病(ad)的关系。方法以165例散发ad患者和174例年龄匹配老年人为对象进行病例-对照研究。用pcr-rflp法检测pon1及载脂蛋白e(apoe)基因多态并进行关联分析。结果ad组与对照组pon1基因gln192arg多态性分布没有显著性差异。研究对象按apoeε4携带状况分层后,各亚组之间基因多态性分布亦无显著性差异。结论pon1基因gln192arg多态性与中国汉族人群ad不存在关联。
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