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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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抑癌基因pten和fhit在口腔鳞癌中的表达及其与cyclind1的相关性
, PP. 79-82
Keywords: 抑癌基因,pten,fhit,cyclind1,口腔癌,免疫组化
Abstract:
目的检测抑癌基因pten、fhit在正常口腔粘膜上皮和口腔鳞癌(oscc)中的表达情况,并探讨其与cyclind1的关系。方法采用免疫组化sp法检测62例oscc中fhit、pten、cyclind1蛋白表达的情况,以12例正常口腔粘膜作对照。结果在正常口腔粘膜中pten均为强阳性表达(12/12),在oscc中24.2%(15/62)表现为pten蛋白表达的缺乏或减少;而fhit在正常口腔粘膜中也均为强阳性表达(12/12),在oscc中17.7%(11/62)表现为fhit蛋白表达缺乏或减少;cyclind1在正常口腔粘膜中91.7%(11/12)表现为阴性或弱阳性表达,在oscc中53.2%(33/62)表现为阳性或强阳性表达;pten与fhit均为阳性或强阳性表达时,37.8%(28/74)cyclind1表现为阴性或弱阳性,其中11例为正常口腔粘膜(占正常组的91.7%)。结论pten、fhit在oscc的发生过程中起着一定的作用;pten/fhit的表达与cyclind1有关,提示pten、fhit能够下调cyclind1的表达。
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