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保护赖氨酸的制备工艺

DOI: 10.3969/j.issn.1671-7627.2003.04.011, PP. 45-48

Keywords: 制备,l-lys,fmoc,boc,保护氨基酸

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Abstract:

保护l-赖氨酸是固相多肽合成的重要原料,其商品价格居高不下.采用fmoc和boc保护策略,对l-lys的α-氨基和ε-氨基保护进行了制备工艺研究,优化选择了其制备条件,将fomc-l-lys(boc)的产品产率由76%提高到88%,产品纯度达到99.6%.

References

[1]  黄惟德,陈常庆.多肽合成[m].北京:科学出版社,1985.
[2]  许家喜,杨俊海.正交保护赖氨酸的合成[j].化学通报(印刷版),2000(1):26-29.doi:10.3969/j.issn.0441-3776.2000.01.006.
[3]  scottjw,parkerd,parrishdr.improvedsynthesisofnε-tertbutyloxycarbonyl-l-lysineandnα-benzyloxycarbonyl-nε-ertbutyloxycarbonyl-l-lysine[j].syntheticcommunications,1981(4):303-314.doi:10.1080/00397918108063610.
[4]  louisacarpino.the9-fluorenylmethyloxycarbonylfamilyofbasesensitiveamino-protectinggroups[j].accountsofchemicalresearch,1987.401-403.doi:10.1021/ar00143a003.
[5]  theodorawgreene,petergmwuts.protectivegroupsinorganicsynthesis[m].newyork:wiley,1999.
[6]  stanislawwiejak,elzbietamasiukiewicz.alargescalesynthesisofmono-anddi-urethanederivativesoflysine[j].chemicalandpharmaceuticalbulletin,1999,(10):1489-1490.
[7]  lapatsanisl,miliasg,froussiosk.synthesisofn-222-(trichloroethoxycarbonyl)-l-aminoacidsandn-(9-fluorenylmethoxycarbonyl)-l-aminoacidsinvolvingsuccinimidoxyanionasaleavinggroupinaminoacidprotection[j].synthesis-stuttgart,1983(8):671-672.doi:10.1055/s-1983-30468.
[8]  johnptischio,nancyhetyei.isocraticreversed-phasehighperformanceliquidchromatographicseparationofunderivatisedtyrosine-relatedpeptidesofthymopoietin32-36pentapeptide[j].journalofchromatography,1982.237-243.doi:10.1016/s0021-9673(00)82522-4.
[9]  刘振南,黄强.fmoc固相合成法[j].广西民族学院学报(自然科学版),1999(2):109-112.doi:10.3969/j.issn.1673-8462.1999.02.012.
[10]  bycroftbw,chanwc,chhabrasr.anovellysineprotectingprocedureforcontinuousflowsolidphasesynthesisofbranchedpeptides[j].journalofthechemicalsociety,chemicalcommunications,1993(9):778-779.doi:10.1039/c39930000778.

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