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OALib Journal期刊
ISSN: 2333-9721
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乙醇注入法制备司帕沙星脂质体
DOI: 10.3969/j.issn.1671-7627.2007.01.008, PP. 32-35
Keywords: 司帕沙星脂质体,乙醇注入,包封率,单因素考察
Abstract:
制备司帕沙星脂质体,单因素考察优化了制备工艺和处方,以提高脂质体的包封率.采用乙醇注入高压均质法制备了司帕沙星脂质体,以透析高效液相色谱法测定了含量和包封率.实验结果表明,司帕沙星脂质体的平均粒径为22.1nm,包封率为47%左右.乙醇注入高压均质法适用于制备司帕沙星脂质体,透析高效液相色谱法操作简单、准确、重复性好,可用于测定司帕沙星脂质体的含量和包封率.
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