以邻甲氧基苯乙酸为起始原料制备酰肼,再与取代苯甲醛在酸性条件下制得8个邻甲氧基苯乙酰席夫碱(2a-2h),产物经红外？p核磁？p质谱？p元素分析确认结构.抑菌性能研究结果表明2b,2h对所选大肠杆菌？p金黄色葡萄球菌？p枯草杆菌？p绿脓杆菌均有一定抑制作用,其中化合物2b对枯草杆菌？p金黄色葡萄球菌表现出极好的抑菌性能.O-methoxy benzene acetic acid was used to produce benzoyl hydrazine,then eight O-methoxy benzene acetic acid schiff were obtained using hydrazide derivatives and eight substituted benzene formaldehyde as starting materials.The structures of these compounds were characterized by IR,1H NMR,MS and elemental analysis.Antibacterial activity research indicated that compounds 2b and 2h had a certain inhibitory effect on Escherichia coli,Staphylococcus aureus,Bacillus subtilis,Pseudomonas aeruginosa while 2b showed good antimicrobial properties on B.Subtilis and S.aureus
