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OALib Journal期刊
ISSN: 2333-9721
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雷公藤红素抑制c2c12细胞增殖及诱导其凋亡
, PP. 93-96
Keywords: 雷公藤红素,c2c12成肌细胞,细胞增殖,细胞凋亡
Abstract:
雷公藤红素(celastrol)是传统草药雷公藤根部有效的提取成分,被广泛用于炎症性疾病如类风湿性关节炎、肾炎等治疗.近年来发现,其能抑制肿瘤细胞增殖,具有诱人的肿瘤治疗应用前景.本研究观察到雷公藤红素会抑制c2c12小鼠骨骼肌母细胞的增殖,并可能通过诱导caspase-3的降解致使c2c12凋亡,提示雷公藤红素临床应用的安全性值得关注.
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