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OALib Journal期刊
ISSN: 2333-9721
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姬菇多糖对急性酒精性肝损伤小鼠的肝组织超微结构的影响
, PP. 85-89
Keywords: 姬菇多糖,急性肝损伤,肝组织,超微结构
Abstract:
目的:研究以热水浸提法从姬菇中提取的姬菇多糖(pcnp)对酒精所致的急性损伤小鼠肝组织超微结构的影响.方法:84只小鼠被随机分为空白对照组、模型组、阳性对照组(150mg/kg？bw)、多糖各剂量组((100、200、400)mg/kg？bw).连续灌胃30d后,给予浓度为50%的乙醇溶液,建立动物急性肝损伤模型.12h后,小鼠脱臼处死,取肝脏制成超薄切片,电镜观察肝组织超微结构的变化.结果:模型组细胞核的核膜不规则、呈锯齿状,线粒体畸形、嵴不清楚、糖原增多、出现空泡,内质网扩张、其膜上附着的核糖体脱失,细胞核周围脂滴数明显增多、胆管微绒毛脱失;姬菇多糖组肝细胞核膜凹凸不平,线粒体肿胀、线粒体内糖原沉积较少,内质网扩张不明显,细胞内脂滴减少.结论:姬菇多糖对酒精性肝损伤小鼠的肝细胞具有保护作用.
| [1] | 鞠辉,魏良洲.酒精性肝病的流行病学现状[j].肝脏,2006,11(1):57-58.
|
| [2] | reubena.alcoholandtheliver[j].currentopinioningastroenterology,2008,24(3):328-338.
|
| [3] | daycp.treatmentofalcoholicliverdisease[j].livertransplantation,2007,13(11suppl.2):69-75.
|
| [4] | 王波.彩色图解姬菇、肺形侧耳栽培新技术[m].成都:四川科学出版社,2003:1-2.
|
| [5] | 郭勇,周洁,谭伟,等.我国姬菇研究现状[j].中国食用菌,2009,28(6):12-13.
|
| [6] | 姜自彬,曹锦花,魏学彦.糙皮侧耳真菌的研究进展[j].中草药,1999,30(1):72-75.
|
| [7] | eluhans,ranogajeca.compositionandnon-volatilecomponentsofcroatianwildediblemushrooms[j].foodchemistry,2011,124(3):1076-1082.
|
| [8] | elmastam,isildako,turkekuli,etal.determinationofantioxidantactivityandantioxidantcompoundsinwildediblemushrooms[j].journaloffoodcompositionandanalysis,2007,20(3):337-345.
|
| [9] | wassersp.medicinalmushroomsasasourceofantitumorandimmunomodulatingpolysaccharides[j].microbiolbiotechnol,2002,60(3):258-274.
|
| [10] | 王峰,陶明煊,程光宇,等.4种食用菌提取物自由基清除作用及降血糖作用的研究[j].食品科学,2009,30(21):343-347.
|
| [11] | elbohik,sabikl,muzanduk,etal.antigenotoxiceffectofpleurotuscornucopiaeextractsonthemutagenesisofsalmonellatyphimuriumta98elicitedbybenzopyreneandoxidativednalesionsinv79hamsterlungcells[j].japanesejournalofveterinaryresearch,2005,52(4):163-172.
|
| [12] | khloodmeb,yoshiharuh,kaampwem,etal.protectiveeffectofpleurotuscornucopiaemushroomextractoncarbontetrachloride-inducedhepatotoxicity[j].japanesejournalofveterinaryresearch,2009,57(2):109-118.
|
| [13] | 徐莉.医学生物学[m].上海:上海科学技术出版社,2005.
|
| [14] | betallerr,northke,brennerda.geneticpolymorphismsandtheprogressionofliverfibrosis:acriticalappraisal[j].hepatology,2003,37:493-503.
|
| [15] | bergeronr,previssf,clinegw,etal.effectof5-aminoimidazone-4-carbo-xamide-1-beta-d-ribofuranosideinfusiononinvivoglucoseandlipidmetabolisminleanandobesezuckerrats[j].diabetes,2001,50:1076-1082.
|
| [16] | malhih,kaufmanrj.endoplasmicreticulumstressinliverdisease[j].jhepatol,2011,54(4):795-809.
|
| [17] | beierji,mclaincj.mechanismsandcellsignalinginalcoholicliverdisease[j].biolchem,2010,391(11):1249-1264.
|
| [18] | songz,joshibs,barves,etal.advancesinalcoholicliverdisease[j].currgastroenterolrep,2004,6(1):71-76.
|
| [19] | 刘洁,李文香,王文亮,等.多糖空间结构与生物活性相关性研究进展[j].农业机械,2011,6(17):153-155.
|
| [20] | 黄芳,蒙义文.活性多糖的研究进展[j].天然产物的研究与开发,1999,11(5):90-97.
|
| [21] | 朱良,沈耀威,赵冠欣,等.橄榄总黄酮对小鼠急性酒精性肝损伤的保护作用[j].食品与机械,2010,26(3):91-93.
|
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