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向helmcop数据库直系同源组添加古菌序列

Keywords: 古菌,orthomcl,helmcop,blast

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Abstract:

含有古菌序列的直系同源组可以在很大程度上便利各种基于helmcop数据的研究,但是目前helmcop直系同源组不含有任何古菌序列.为了向helmcop直系同源组添加古菌序列,以1个orthomcl-db网站工具的分配方法为依据,我们将29种古菌物种模式菌株的蛋白质组数据,通过blast比对和orthomcl分析,逐步添加至各个helmcop直系同源组中.结果显示,21326条古菌序列被成功地分配给了1954个helmcop直系同源组中,而其他2821条古菌序列被归类至no_group类别.这些分配结果得到了良好blast匹配数据的支持.一些自由生活物种包括caenorhabditisjaponica、大豆和拟南芥在研究中也受到了关注,因为这些物种相当多的基因在古菌物种内有同源基因.

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