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OALib Journal期刊
ISSN: 2333-9721
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水溶性c60-脱氢枞胺衍生物的合成及生物活性
DOI: 10.3969/j.jssn.1000-2006.2012.02.007, PP. 29-34
Keywords: 水溶性c60-脱氢枞胺衍生物,hiv-1反转录酶,rtaqdna聚合酶,生物活性
Abstract:
以c60-脱氢枞胺吡咯烷衍生物和c60-脱氢枞胺氮烯加成物为原料,通过两种不同的水性化途径分别合成了两种水溶性的c60-脱氢枞胺富勒醇衍生物和两种水溶性的c60-脱氢枞胺甘氨酸衍生物。产物经tem、ft-ir、esi-ms、1hnmr和hplc等分析方法检测确认为目标产物,且为加成度不同的混合物。对合成出的4种水溶性c60-脱氢枞胺衍生物进行了生物活性测试。结果表明,4种水溶性c60-脱氢枞胺衍生物对rtaqdna聚合酶和hiv-1反转录酶均表现出一定的抑制作用,对卵巢癌细胞株几乎不表现出抑制活性。
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