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OALib Journal期刊
ISSN: 2333-9721
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左旋β蒎烯选择性氧化合成右旋诺蒎酮的研究
DOI: 10.3969/j.jssn.1000-2006.2010.02.021, PP. 89-94
Keywords: (-)β蒎烯,选择性氧化,(+)诺蒎酮
Abstract:
以(-)β蒎烯为原料，经选择性氧化合成(+)诺蒎酮，分析了在不同氧化剂及溶剂体系下β蒎烯的氧化行为。研究了β蒎烯与高锰酸钾摩尔比、硫酸与高锰酸钾摩尔比、溶剂类型、反应温度、反应时间等因素对β蒎烯氧化转化率和诺蒎酮产物选择性的影响。结果表明，左旋β蒎烯选择性氧化合成右旋诺蒎酮适宜的氧化工艺条件：β蒎烯与高锰酸钾摩尔比为1∶3，硫酸与高锰酸钾摩尔比0.054∶1,以丙酮为溶剂，反应温度为15~25℃，反应时间为5h。此条件下β蒎烯转化率为94.15%，诺蒎酮选择性为89.19%，诺蒎酮得率为83.97%，纯度为95.29%，比旋光度为[α]18d+33.86°(c1.01,chcl3)。另外，采用ir、gc-ms、1hnmr和13cnmr等对诺蒎酮结构进行了表征。
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