蓝刺头花絮水提物的降血糖作用研究
Anti-hyperglycemic activity of water extract from Echinops latifolius Tausch blossoms

【目的】研究蓝刺头花絮水提物的降血糖作用。【方法】采用煎煮法制备蓝刺头花絮水提物。使用四氧嘧啶诱导糖尿病小鼠模型，并随机分为4组，每组10只，蓝刺头高、中、低剂量组小鼠每天分别灌胃1.00，0.50和0.25 g/mL的蓝刺头花絮水提物，对照组灌等量蒸馏水，于试验0，7，14和21 d测定糖尿病小鼠空腹血糖、体质量；21 d测定小鼠口服糖耐量、肝糖原、血清胰岛素、胰高血糖素及肾上腺素的含量。【结果】蓝刺头花絮水提物能够显著降低糖尿病小鼠的空腹血糖，改善糖尿病小鼠的口服糖耐量，升高肝糖原及血清胰岛素水平，极显著降低血清肾上腺素含量，对体质量和血清胰高血糖素含量无显著影响。【结论】蓝刺头花絮水提物能够降低糖尿病小鼠的血糖水平，且呈剂量依赖关系。
【Objective】This study investigated the hypoglycemic effect of water extract from Echinops latifolius Tausch blossoms (WET).【Method】Decocting method was used to prepare water extract from WET blossoms.Diabetic mice model was set up with alloxan and all mice were divided randomly into 4 groups,with 10 in each group.The high-dose,middle-dose,and low dose mice were fed WET with concentrations of 1.00,0.50 and 0.25 g/mL directly,respectively,while the control group was fed with distilled water.Body weight and fasting blood glucose concentration of each mouse were determined at 0,7,14 and 21 d.In addition,oral glucose tolerance and contents of hepatic glycogen,serum insulin,glucagon,and adrenalin were determined at the end of the 21 d.【Result】WET significantly lowered fasting blood glucose,improved oral glucose tolerance,increased the hepatic glycogen and serum insulin,and depressed the serum adrenalin.It had no significant effect on body weight and blood glucagon of diabetic mice.【Conclusion】It was confirmed that WET can reduce blood glucose in diabetic mice and with dose-dependent relations