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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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大鼠体内生地黄吸收成分分析及其药动学研究
, PP. 1464-1470
Keywords: 生地黄,梓醇,筋骨草醇,药动学
Abstract:
本文采用液质联用方法,通过比较标准品、生地黄水提物、空白血浆和生地黄给药后不同时间的大鼠血浆样品的紫外、正负离子全扫描图、提取离子流图及选择性反应监测图,发现梓醇和筋骨草醇是生地黄主要吸收成分,桃叶珊瑚苷、二氢梓醇、地黄苷a(或地黄苷b、密力特苷)和地黄苷d亦有吸收。建立了大鼠血浆梓醇和桃叶珊瑚苷的定量分析方法及其他吸收成分的半定量分析方法。大鼠灌胃给予生地黄水提物6g·kg-1后,梓醇和筋骨草醇cmax、t1/2和auc0-∞分别为(2349.05±1438.34)和(104.25±82.05)ng·ml-1、(0.86±0.32)和(0.96±0.37)h,(4407.58±2734.89)和(226.66±188.38)ng·h·ml-1,tmax均为1.00h。梓醇和筋骨草醇的吸收和消除均很快。
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