|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
丹参酮iia激活nrf2/are通路保护雷公藤甲素所致急性肝损伤
, PP. 1397-1402
Keywords: 丹参酮iia,雷公藤甲素,nrf2/are通路,肝损伤
Abstract:
研究丹参酮iia(tanshinoneiia,tan)对雷公藤甲素(triptolide,tp)所致小鼠急性肝损伤的保护作用及相关机制。腹腔注射tp(1mg·kg-1)建立小鼠急性肝损伤模型。检测血清中ast、alt和ldh活性,测定肝组织中gsh、gst、gsh-px、sod、cat和mda含量,he染色观察肝组织病理改变,westernblotting检测肝组织细胞核内nrf2的表达,实时定量pcr检测肝组织gclc、nqo1和ho-1mrna表达水平。结果显示,与tp组比较,tan保护组(10和30mg·kg-1)血清ast、alt和ldh活性明显降低,肝组织gsh、gst、sod及cat明显升高,而mda明显降低,肝组织病理改变也明显减轻。同时tan保护组能显著诱导肝组织中的nrf2转位入核,其下游靶基因gclc、nqo1和ho-1mrna表达水平也显著升高。研究表明,tan对tp所致急性肝损伤有保护作用,其机制与激活nrf2/are通路有关。
| [1] | linn,liuc,xiaoc,etal.triptolide,aditerpenoidtriepoxide,suppressesinflammationandcartilagedestructionincollagen-inducedarthritismice[j].biochempharmacol,2007,73:136-146.
|
| [2] | zhuw,huh,qiup,etal.triptolideinducesapoptosisinhumananaplasticthyroidcarcinomacellsbyap53-independentbutnf-kappab-relatedmechanism[j].oncolrep,2009,22:1397-1401.
|
| [3] | liul,jiangz,liuj,etal.sexdifferencesinsubacutetoxicityandhepaticmicrosomalmetabolismoftriptolideinrats[j].toxicology,2010,271:57-63.
|
| [4] | sunq,mengqt,jiangy,etal.ginsenosiderb1attenuatesintestinalischemiareperfusioninducedrenalinjurybyactivatingnrf2/arepathway[j].molecules,2012,17:7195-7205.
|
| [5] | okadak,warabie,sugimotoh,etal.nrf2inhibitshepaticironaccumulationandcounteractsoxidativestress-inducedliverinjuryinnutritionalsteatohepatitis[j].jgastroenterol,2012,47:924-935.
|
| [6] | xiawj,yangm,foktf,etal.partialneuroprotectiveeffectofpretreatmentwithtanshinoneiiaonneonatalhypoxia-ischemiabraindamage[j].pediatrres,2005,58:784-790.
|
| [7] | tsaimy,yangrc,wuht,etal.anti-angiogeniceffectoftanshinoneiiainvolvesinhibitionofmatrixinvasionandmodificationofmmp-2/timp-2secretioninvascularendothelialcells[j].cancerlett,2011,310:198-206.
|
| [8] | xuex,gongl,qix,etal.knockoutofhepaticp450reductaseaggravatestriptolide-inducedtoxicity[j].toxicollett,2011,205:47-54.
|
| [9] | zhanghs,wangsq.nrf2isinvolvedintheeffectoftanshinoneiiaonintracellularredoxstatusinhumanaorticsmoothmusclecells[j].biochempharmacol,2007,73:1358-1366.
|
| [10] | lins,yuxy,quehq,etal.diterpenesconstituentsoftripterygiumwilfordii[j].actapharmsin(药学学报),2005,40:632-635.
|
| [11] | nib,jiangz,huangx,etal.malereproductivetoxicityandtoxicokineticsoftriptolideinrats[j].arzneimittelforschung,2008,58:673-680.
|
| [12] | fuq,huangx,shub,etal.inhibitionofmitochondrialrespiratorychainisinvolvedintriptolide-inducedliverinjury[j].fitoterapia,2011,82:1241-1248.
|
| [13] | lim,jinj,lij,etal.schisandrinbprotectsagainstnephrotoxicityinducedbycisplatininhk-2cellsvianrf2-areactivation[j].actapharmsin(药学学报),2012,47:1434-1439.
|
| [14] | bettomr,lazarottolf,watanabett,etal.effectsoftreatmentwithenalaprilonhepatotoxicityinducedbyacetaminopheninmice[j].naunynschmiedebergsarchpharmacol,2012,385:933-943.
|
| [15] | liuy,chenh,jiangy.protectiveeffectoftanshinoneiiaonacutehepaticinjuryinmice[j].jchinmed(中药材),2001,24:588-589.
|
| [16] | bairdl,dinkova-kostovaat.thecytoprotectiveroleofthekeap1-nrf2pathway[j].archtoxicol,2011,85:241-272.
|
| [17] | lij,jinj,lim,etal.roleofnrf2inprotectionagainsttriptolide-inducedtoxicityinratkidneycells[j].toxicollett,2012,213:194-202.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
