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OALib Journal期刊
ISSN: 2333-9721
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应用因子分析法评价常用片剂辅料的形变行为
, PP. 1475-1483
Keywords: 因子分析,形变行为,压片,粉体压缩,辅料
Abstract:
实验考察片剂辅料物理性质和形变行为的相关性,并根据其在压缩过程中的塑性表现进行排名。测定各种辅料的物理性质后,用korschxp1进行压片,以heckle方程、压缩功和模内的弹性松弛为评价形变行为的压缩参数,选择典型相关分析考察物理性质和压缩参数两者的关系,同时用因子分析法对所有辅料的形变行为进行综合评价。典型变量显示,真密度(absolutedensity,ρa)与塑性系数(plasticcoefficient,pl)呈负相关、与屈服应力(yieldpressure,yp)呈正相关,压缩度(compressiondegree,cp)与pl呈正相关,弹性松弛(fastelasticstretch,fes)和yp呈负相关。结合压缩参数数据,采用因子综合得分能够将辅料分别进行塑性排名分类为高(-0.56
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