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OALib Journal期刊
ISSN: 2333-9721
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葛根芩连汤对2型糖尿病大鼠的治疗作用及其机制探讨
, PP. 1415-1421
Keywords: 葛根芩连汤,2型糖尿病,糖代谢,胰岛素抵抗,氧化应激
Abstract:
为考察葛根芩连汤(gd)抗糖尿病作用及其机制,建立了高脂饲料联合链脲佐菌素(stz)诱发的大鼠2型糖尿病模型,研究了gd对糖代谢、胰岛素抵抗和氧化应激反应的影响。结果表明,gd可增加模型大鼠肝糖元合成,显著降低空腹血糖和空腹血清胰岛素含量,升高胰岛素敏感指数;增加血清超氧化物歧化酶(sod)含量,降低丙二醛(mda)水平;改善胰岛组织和肾组织形态。提示gd可能通过改善糖代谢、改善胰岛素抵抗、提高组织对胰岛素的敏感性和增强机体抗氧化能力,发挥治疗2型糖尿病和保护受损胰岛β细胞的功能。
| [1] | zhaolh,lianfm,jihy,etal.clinicalexamplesoftreatmentfortype2diabetesbyprofessortongxiao-linusinggegenqinliandecoction[j].chinjexptraditmedform(中国实验方剂学杂志),2011,17:249-251.
|
| [2] | jinl,anwc,anwd.120treatmentcasesofgegenqinliandecoctionontype2diabetes[j].jchangchununivtraditchinmed(长春中医药大学学报),2012,28:315.
|
| [3] | wangf,hehl.treatmentexperiencefortype2diabetesbyprofessorzhangfa-rongusinggegenqinliandecoction[j].jtraditchinmed(中医杂志),2005,46:103.
|
| [4] | ligw,panxr.anewinsulin-sensitivityindexforthepopulation-basedstudy[j].chinjinternmed(中华内科杂志),1993,32:656-660.
|
| [5] | wanghl,wangq,yincm.thestudyonmechanismofemodinandberberineimprovingtheinsulinresistanceinhepg2cells[j].chinjpathophysiol(中国病理生理杂志),2009,25:2044-2046,2049.
|
| [6] | giuglianod,cerielloa,paolissog.oxidativestressanddiabeticvascularcomplications[j].diabetescare,1996,19:257-267.
|
| [7] | roloap,palmeriacm.diabetesandmitochondrialfunction:roleofhyperglycemiaandoxidativestress[j].toxicolapplpharmacol,2006,212:167-178.
|
| [8] | chenrp.studyonhypoglycemicmechanismofgegenqinliandecoctionexperimentaldiabeticanimalmodel(葛根芩连汤对试验性糖尿病动物模型降血糖机制的初步研究)[d].jilin:changchunnormaluniversity,2011.
|
| [9] | taosg,panjq,kuangss,etal.effectofpuerarinoninsulinsensitivity,bloodglucoseandlipidinmetabolicsyndrome-type2diabeticrats[j].chinapharm(中国药业),2008,17:10-12.
|
| [10] | waisundaravy,siusy,hsua,etal.baicalinupregulatesthegeneticexpressionofantioxidantenzymesintype-2diabeticgoto-kakizakirats[j].lifesci,2011,88,23-24:1016-1025.
|
| [11] | zhaohy,yangsj,mayp,etal.effectoflicoriceflavonoidsonantioxidativecapabilityintype2diabeticrats[j].chinjmodmed(中国现代医学杂志),2011,21:4359-4362.
|
| [12] | zhangj,liuyz,wangys,etal.optimizationofextractiontechnologyforgegenqinliandecoctionwithmulti-indexcomprehensiveevaluationmethod[j].chinjexptraditmedform(中国实验方剂学杂志),2012,18:1-3.
|
| [13] | zhangm,lüxy,lij,etal.thecharacterizationofhigh-fatdietandmultiplelow-dosestreptozotocininducedtype2diabetesratmodel[j].expdiabetesres,2008,704045.
|
| [14] | hongyuz,jharnas,jaemanb,etal.rosiglitazonereducesrenalandplasmamarkersofoxidativeinjuryandreversesurinarymetaboliteabnormalitiesintheameliorationofdiabeticnephropathy[j].amjphysiolrenalphysiol,2008,295:1071-1081.
|
| [15] | chenhy,wangjh,gengm,etal.protectiveeffectofextractofapocynumvenetumonkidneysofstreptozotocin-induceddiabeticrats[j].actapharmsin(药学学报),2010,45:26-30.
|
| [16] | hongh,wangqm,zhaozp,etal.studiesonantidiabeticeffectsofcortexmoutanpolysaccharide-2bintype2diabetesmellitusrats[j].actapharmsin(药学学报),2003,38:255-259.
|
| [17] | haffnersm,gonzalezc,miettinenh.aprospectiveanalysisofthehomamodel[j].diabetescare,1996,19:1138-1141.
|
| [18] | weiyy.effectofpomegranateflowerpolyphenolonglucoseofdiabetesratsandmechanismresearch(石榴花多酚对糖尿病大鼠血糖血脂的影响及其作用机制的研究)[d].xinjiang:xinjiangmedicaluniversity,2011:33.
|
| [19] | wangh.thestudyoftheearlyinterventionofanthraquinoneofrhizomapolygonicuspidationdiabeticnephropathy(虎杖总蒽醌对糖尿病肾病早期干预作用研究)[d].beijing:beijinguniversityofchinesemedicine,2008:64.
|
| [20] | srinivasank,viswanadb,asratl,etal.combinationofhigh-fatdiet-fedandlow-dosestreptozotocin-treatedrat:amodelfortype2diabetesandpharmacologicalscreening[j].pharmacolres,2005,52:313-320.
|
| [21] | hur,lib,zhaoq,etal.effectsofpuerarinondifferentiationof3t3-l1prcadipocytesandglucosemetabolismininsulin-resistant3t3-l1adipocytes[j].pharmacolclinchinmatermed(中药药理与临床),2012,28:41-43.
|
| [22] | yinj,hurm,tangjf,etal.glucose-loweringeffectofberberineinvitro[j].actajshanghaisecondmeduniv(上海第二医科大学学报),2001,21:425-427.
|
| [23] | kahnse,hullr,utzschneiderkm.mechanismslinkingobesitytoinsulinresistanceandtype2diabetes[j].nature,2006,444:840-846.
|
| [24] | liuzx.effectandmechanism'spreliminarydiscussiononshuang-yihypoglycemicprescriptionintype2diabeticrats(双益降糖方对2型糖尿病大鼠的作用及其机制初探)[d].hebei:hebeiuniteduniversity,2011:2.
|
| [25] | renhy,tangdc.roleofthevalidcomponentofkudzuvinerootintreatingdiabetesanditscomplications[j].chinjclinrehabil(中国临床康复),2005,9:134-135.
|
| [26] | wus,lufe,dongh,etal.effectsofberberineonthepancreaticbetacellapoptosisinratswithinsulinresistance[j].chinjintergrtraditchinwestmed(中国中西医结合杂志),2011,31:1383-1388.
|
| [27] | panjj,xiaoly,hanc,etal.effectsofgegenqinliandecoctiononantagonizingimpairedglucosetoleranceind-galactose-inducedrats[j].guangdongpharmj(广东药学),2004,14:31-33.
|
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