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OALib Journal期刊
ISSN: 2333-9721
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nmr技术在天然产物活性物质发现及其药理学研究中的应用
, PP. 1383-1389
Keywords: hplc-nmr-ms,代谢组学,活性物质
Abstract:
hplc-nmr-ms联用技术在复杂混合物微量物质结构鉴定和代谢轮廓建立过程中内源性及外源性物质鉴定中的应用,表明其已成为天然产物活性物质药物化学、药理学及药代动力学研究中有用的分析工具。基于nmr技术的代谢组学方法可以精确刻画带有疾病特色的、包含各种疾病相关通路的综合代谢表型,可极大地丰富和补充传统的疾病评价指标,从而可用于天然产物活性物质毒理学研究、剂量优化、活性物质筛选及药效学评价等药理学研究领域。基于nmr技术的联用技术与代谢组学方法结合,将加快天然产物活性物质发现的速度,并提高其药理学评价的效率。
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