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OALib Journal期刊
ISSN: 2333-9721
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组蛋白去乙酰化酶6的结构、功能及选择性抑制剂的研究进展
, PP. 7-14
Keywords: 表观遗传学,组蛋白去乙酰化酶6,选择性抑制剂
Abstract:
组蛋白去乙酰化酶6(hdac6)是组蛋白去乙酰化酶家族中独具特色的一员。该酶具有两个去乙酰化功能区,可特异性催化非组蛋白底物,参与并调节众多生理或病理进程。目前已报道的选择性hdac6抑制剂结构种类较多,有的正处于临床试验阶段。本文将对hdac6的结构、功能及其选择性抑制剂的研究进展进行综述。
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