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OALib Journal期刊
ISSN: 2333-9721
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基于酶敏感机制的可激活细胞穿透肽在靶向输送系统中的应用
, PP. 141-147
Keywords: 细胞穿透肽,可激活细胞穿透肽,酶敏感
Abstract:
细胞穿透肽的细胞膜穿透作用借助于一种非选择性和受体非依赖性的方式。该特点使得细胞穿透肽介导的细胞摄取过程适用于较广泛的细胞类型,而这种普遍性对于癌症治疗和诊断领域的应用无疑是重大障碍。因此,将体循环给药的细胞穿透肽惰化形式在肿瘤等病变区域选择性地转变为活化态成为研究热点。本文重点关注引入酶敏感机制的可激活细胞穿膜肽及其靶向递送系统,对此类传递载体的研究概况进行综述。
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