|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
奥扎格雷两种晶型在大鼠体内的药代动力学研究
, PP. 218-221
Keywords: 奥扎格雷,晶型,药代动力学,hplc
Abstract:
研究奥扎格雷两种晶型固体灌胃后,在sd大鼠胃肠道的吸收过程,评价其优势药物晶型,探讨该药物晶型状态对临床用药的影响。sd大鼠灌胃给予不同晶型奥扎格雷固体原料药,采用高效液相色谱法测定血浆中奥扎格雷的浓度,计算其在大鼠体内的药代动力学参数并比对不同晶型之间的差异。大鼠经口给予固体奥扎格雷晶型ⅰ和晶型ⅱ后,血液中奥扎格雷cmax分别为32.72±17.04和34.01±19.13mg·l-1,auc0-t分别为61.14±14.76和85.56±18.08mg·l-1？h,t1/2分别为1.53±0.51和4.73±3.00h。大鼠口服不同晶型奥扎格雷后,晶ⅱ型血药浓度-时间曲线下面积大于晶ⅰ型,半衰期较长,为优势晶型,提示在该药物的生产中需要注意晶型的控制。
| [1] | dugh,lvy.optimaldrugpolimorphsmofsolidcompound[j].chinpharmj(中国药学杂志),2010,45:5-11.
|
| [2] | zhangwg,liucx.studyonbioavailabilityofdrugpolymorphism[j].tianjinpharm(天津药学),2007,19:59-61.
|
| [3] | lvy,dugh,yur,etal.substanceandpreparationofozagrelnewpolymorphformⅱanddrugcompositionandusage:cn,104098514a[p].2014-10-15.
|
| [4] | gaomts,zhangha.pkstudyofthreeofomeprazolepolymorphsinrat[j].chinpharmlett(中国药理通讯),2010,27:52-53.
|
| [5] | yanlq,jino,guoxj.studyonpharmacokineticsofozagrelinwistarrats[j].chinapharm(中国药业),2009,18:12-13.
|
| [6] | yaoxq,chengh.detectionofozagrelpharmaceuticalwithhplc[j].guangdongpharm(广东药学),2005,15:13-15.
|
| [7] | opindrugdiscovdev,2003,6:550-560.
|
| [8] | yulx,furnessms,rawa,etal.scientificconsiderationsofpharmaceuticalsolidpolymorphisminabbreviatednewdrugapplications[j].pharmres,2003,20:531-536.
|
| [9] | byrns,pfeifferr,ganeym,etal.pharmaceuticalsolids:astrategicapproachtoregulatoryconsiderations[j].pharmres,1995,12:945-954.
|
| [10] | pangyn,yingk.polymorphismofdrugs[j].westchinajpharmsci(华西药学杂志),2000,15:197-200.
|
| [11] | fanglh,hegr,wanghy.strategyofcompoundpolymorphbioactivitystudyinearlydruggabilityevaluation[j].chinpharmj(中国药学杂志),2013,48:497-500.
|
| [12] | sajp.30casesofcombinationtreatmentofhydroxy-fasudilandozagrelontransientcerebralischemia[j].chinapharm(中国药业),2011,20:50-51.
|
| [13] | wulj,yubq,zhoulj.combinationtherapyofedara-voneandozagrelonprogressivecerebralinfarction[j].henanmedres(河南医学研究),2011,20:438-439.
|
| [14] | wujy.combinationtreatmentofozagrelandbetahistineonvertebrobasilarinsufficiency[j].chincommunitydrmedspec(中国社区医师医学专业),2011,12:69.
|
| [15] | classd.theimportanceofcharacterizingthecrystalformofthedrugsubstanceduringdrugdevelopment[j].curr
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
