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OALib Journal期刊
ISSN: 2333-9721
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mapks与keap1-nrf2-are信号通路的窜扰作用在慢性阻塞性肺疾病中的作用及意义
, PP. 133-140
Keywords: 慢性阻塞性肺疾病,有丝分裂素激活蛋白激酶类,核因子e2相关因子2
Abstract:
慢性阻塞性肺疾病(chronicobstructivepulmonarydisease,copd)是一种可预防和治疗的疾病,与有害颗粒或气体对肺损伤有关,病理特征为气流受限、慢性呼吸道炎症,其主要病理表现为炎症反应、黏液分泌过量、氧化应激和上皮细胞凋亡。现代研究表明,mapks与keap1-nrf2-are信号通路参与调控炎症、氧化应激等病理过程。本文重点探讨以上信号通路在炎症反应、黏液分泌过量、氧化应激和上皮细胞凋亡中的相互影响,并在此基础上关注与mapks及keap1-nrf2-are信号通路相关的药物,以期阐明mapks和keap1-nrf2-are信号通路及其窜扰作用在调控copd病理生理中的重要作用和意义,同时为copd防治的药物研究和开发提供更多思路。
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