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OALib Journal期刊
ISSN: 2333-9721
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运用基于高通量测序和大数据挖掘的元基因组学方法分析中药制剂的物种成分
, PP. 272-277
Keywords: 中药,物种成分,元基因组学,高通量测序,大数据挖掘
Abstract:
中药制剂质量评价以化学成分分析为主,而物种成分分析近年来引起了中医药界的极大关注,特别是对于丸剂类中药制剂的质量评价更为重要。建立中药制剂物种成分的快速、准确、系统的分析方法,是实现中药现代化、产业化和国际化的关键之一。中药制剂物种成分分析的实质是对包含多个生物物种的混合体系(混合生物样本)的物种鉴定。基于高通量测序和大数据挖掘技术的元基因组学方法是目前认识、分析生物混合体系结构和功能最有效、最重要的方法之一。利用元基因组学方法将有助于建立中药制剂的物种评价方法。通过选择合适的dna分子标记,可对配伍处方药材物种进行鉴别,同时通过大规模数据分析和挖掘鉴别制剂中的混伪品、有毒动植物或受保护动植物的成分,以及在生产过程引入的生物杂质,从而为中药制剂的有效性、安全性和合法性提供评价依据。
| [1] | yuzb,luoy.importandexportanalysisoftraditionalchinesemedicinein2012[j].modchinmed(中国现代中药),2013:143-146.
|
| [2] | yuzb.importandexportanalysisoftraditionalchinesemedicinein2013[j].modchinmed(中国现代中药),2014,16:151-154.
|
| [3] | venterjc,remingtonk,heidelbergjf,etal.environmentalgenomeshotgunsequencingofthesargassosea[j].science,2004,304:66-74.
|
| [4] | hunterci,mitchella,jonesp,etal.metagenomicanalysis:thechallengeofthedatabonanza[j].briefbioinform,2012,13:743-746.
|
| [5] | maym.lifesciencetechnologies:bigbiologicalimpactsfrombigdata[j].science,2014,344:1298-1300.
|
| [6] | hazentc,rochaam,techtmannsm.advancesinmonitoringenvironmentalmicrobes[j].curropinbiotechnol,2013,24:526-533.
|
| [7] | wangj,mclenachanpa,biggspj,etal.environmentalbio-monitoringwithhigh-throughputsequencing[j].briefbioinform,2013,14:575-588.
|
| [8] | sommermo,churchgm,dantasg.afunctionalmetagenomicapproachforexpandingthesyntheticbiologytoolboxforbiomassconversion[j].molsystbiol,2010,6:360.
|
| [9] | http://www.ncbi.nlm.nih.gov/nuccore/.
|
| [10] | teelingh,glocknerfo.currentopportunitiesandchallengesinmicrobialmetagenomeanalysis-abioinformaticperspective[j].briefbioinform,2012,13:728-742.
|
| [11] | coghlanml,hailej,houstonj,etal.deepsequencingofplantandanimaldnacontainedwithintraditionalchinesemedicinesrevealslegalityissuesandhealthsafetyconcerns[j].plosgenet,2012,8:e1002657.
|
| [12] | chengx,sux,chenx,etal.biologicalingredientanalysisoftraditionalchinesemedicinepreparationbasedonhigh-throughputsequencing:thestoryforliuweidihuangwan[j].scirep,2014,4:5147.
|
| [13] | hebertpd,cywinskaa,ballsl.biologicalidentificationsthroughdnabarcodes[j].procbiolsci,2003,270:313-321.
|
| [14] | hanjp,limn,luok,etal.identificationofdaturaeflosanditsadulterantsbasedondnabarcodingtechnique[j].actapharmsin(药学学报),2011,46:1408-1412.
|
| [15] | jisg,pansl,wangj,etal.phylogenyrelationshipandmolecularidentificationoftenhuperziaspecies(huperziaceae)basedonmarkgenesequences[j].chinajchinmatermed(中国中药杂志),2007,32:1971-1975.
|
| [16] | chej,tangl,liuyj,etal.molecularidentityofcrocussativusanditsmisusedsubstitutesbyitssequence[j].chinajchinmatermed(中国中药杂志),2007,32:668-671.
|
| [17] | lousk,wongkl,lim,etal.anintegratedwebmedicinalmaterialsdnadatabase:mmdbd(medicinalmaterialsdnabarcodedatabase)[j].bmcgenomics,2010,11:402.
|
| [18] | chensl,yaoh,hanjp,etal.validationoftheits2regionasanoveldnabarcodeforidentifyingmedicinalplantspecies[j].plosone,2010,5:e8613.
|
| [19] | pangx,songj,zhuy,etal.applyingplantdnabarcodesforrosaceaespeciesidentification[j].cladistics,2010,27:165-170.
|
| [20] | taberletp,coissace,pompanonf,etal.powerandlimitationsofthechloroplasttrnl(uaa)intronforplantdnabarcoding[j].nucleicacidsres,2007,35:e14.
|
| [21] | chensl,pangxh,yaoh,etal.identificationsystemandperspectivefordnabarcodingtraditionalchinesemateriamedica[j].worldscitechnol/modtraditchinmedmatermed(世界科学技术:中医药现代化),2012,13:747-754.
|
| [22] | zhouq,sux,jingg,etal.meta-qc-chain:comprehensiveandfastqualitycontrolmethodformetagenomicdata[j].genomicsproteomicsbioinformatics,2014,12:52-56.
|
| [23] | altschulsf,gishw,millerw,etal.basiclocalalignmentsearchtool[j].jmolbiol,1990,215:403-410.
|
| [24] | husondh,auchaf,qij,etal.megananalysisofmetagenomicdata[j].genomeres,2007,17:377-386.
|
| [25] | handelsmanj,rondonmr,bradysf,etal.molecularbiologicalaccesstothechemistryofunknownsoilmicrobes:anewfrontierfornaturalproducts[j].chembiol,1998,5:r245-r249.
|
| [26] | handelsmanj.metagenomics:applicationofgenomicstounculturedmicroorganisms[j].microbiolmolbiolrev,2004,68:669-685.
|
| [27] | hugenholtzp,tysongw.microbiology:metagenomics[j].nature,2008,455:481-483.
|
| [28] | tringesg,vonmeringc,kobayashia,etal.comparativemetagenomicsofmicrobialcommunities[j].science,2005,308:554-557.
|
| [29] | yangf,zengx,ningk,etal.salivamicrobiomesdistinguishcaries-activefromhealthyhumanpopulations[j].ismej,2011,6:1-10.
|
| [30] | gillsr,popm,deboyrt,etal.metagenomicanalysisofthehumandistalgutmicrobiome[j].science,2006,312:1355-1359.
|
| [31] | qinj,liy,caiz,etal.ametagenome-wideassociationstudyofgutmicrobiotaintype2diabetes[j].nature,2012,490:55-60.
|
| [32] | desantistz,hugenholtzp,larsenn,etal.greengenes,achimera-checked16srrnagenedatabaseandworkbenchcompatiblewitharb[j].applenvironmicrobiol,2006,72:5069-5072.
|
| [33] | chengx,chenx,sux,etal.dnaextractionprotocolforbiologicalingredientanalysisofliuweidihuangwan[j].genomicsproteomicsbioinformatics,2014,12:137-143.
|
| [34] | chasemw,salaminn,wilkinsonm,etal.landplantsanddnabarcodes:short-termandlong-termgoals[j].philostransrsoclondbiolsci,2005,360:1889-1895.
|
| [35] | ningsp,yanhf,haog,etal.currentadvancesofdnabarcodingstudyinplants[j].biodivsci(生物多样性),2008,16:417-425.
|
| [36] | sux,panw,songb,etal.parallel-meta2.0:enhancedmetagenomicdataanalysiswithfunctionalannotation,highperformancecomputingandadvancedvisualization[j].plosone,2014,9:e89323.
|
| [37] | sux,xuj,ningk.parallel-meta:efficientmetagenomicdataanalysisbasedonhigh-performancecomputation[j].bmcsystbiol,2012,6:s16.
|
| [38] | hamadym,lozuponec,knightr.fastunifrac:facilitatinghigh-throughputphylogeneticanalysesofmicrobialcommunitiesincludinganalysisofpyrosequencingandphylochipdata[j].ismej,2010,4:17-27.
|
| [39] | lozuponec,knightr.unifrac:anewphylogeneticmethodforcomparingmicrobialcommunities[j].applenvironmicrobiol,2005,71:8228-8235.
|
| [40] | sux,wangx,jingg,etal.gpu-meta-storms:computingthestructuresimilaritiesamongmassiveamountofmicrobialcommunitysamplesusinggpu[j].bioinformatics,2014,30:1031-1033.
|
| [41] | sux,xuj,ningk.meta-storms:efficientsearchforsimilarmicrobialcommunitiesbasedonanovelindexingschemeandsimilarityscoreformetagenomicdata[j].bioinformatics,2012,28:2493-2501.
|
| [42] | rossha,murugans,liwls.testingthereliabilityofgeneticmethodsofspeciesidentificationviasimulation[j].systbiol,2008,57:216-230.
|
| [43] | guindons,dufayardjf,lefortv,etal.newalgorithmsandmethodstoestimatemaximum-likelihoodphylogenies:assessingtheperformanceofphyml3.0[j].systbiol,2010,59:307-321.
|
| [44] | shahn,tangh,doaktg,etal.comparingbacterialcommunitiesinferredfrom16srrnagenesequencingandshotgunmetagenomics[j].pacsympbiocomput,2011:165-176.
|
| [45] | parksdh,beikorg.identifyingbiologicallyrelevantdifferencesbetweenmetagenomiccommunities[j].bioinformatics,2010,26:715-721.
|
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