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OALib Journal期刊
ISSN: 2333-9721
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慢性不可预见性温和应激模型大鼠的肝脏药物代谢酶活性变化研究
, PP. 319-325
Keywords: 慢性不可预见性温和应激,液质联用,鸡尾酒法,细胞色素p450
Abstract:
采用鸡尾酒(cocktail)探针药物法研究慢性不可预见性温和应激(chronicunpredictablemildstress,cums)造成的抑郁状态对大鼠体内6种cyp450亚酶活性的影响。根据katz法建立cums大鼠抑郁模型;分别选用甲苯磺丁脲、氯唑沙宗、茶碱、咪达唑仑、奥美拉唑及右美沙芬作为大鼠cyp2c6、cyp2e1、cyp1a2、cyp3a2、cyp2d1、cyp2d2的探针底物,采用液质联用法(lc-ms/ms)测定对照组与模型组大鼠体内6种混合探针的血药浓度,计算药动学参数。结果表明,茶碱和氯唑沙宗代谢显著加快(p<0.01),甲苯磺丁脲、右美沙芬、奥美拉唑、咪达唑仑的代谢无显著差异。结果说明,慢性不可预见性温和应激造成的抑郁状态对cyp1a2有强诱导、对cyp2e1有中强诱导作用。
| [1] | zhangfx,zhangh,jianglf.clinicalstudyofdepression[j].shandongjtraditchinmed(山东中医杂志),2010,29:61-62.
|
| [2] | pavm,kovaruh,fiserovaa,etal.neurobiologicalaspectsofdepressivedisorderandantidepressanttreatment:roleofglia[j].physiolres,2008,57:151-164.
|
| [3] | manosrc,kanterjw,buscham.acriticalreviewofassessmentstrategiestomeasurethebehavioralactivationmodelofdepression[j].clinpsycholrev,2010,30:547-561.
|
| [4] | hamanic,machadodc,hipolidedc,etal.deepbrainstimulationreversesanhedonic-likebehaviorinachronicmodelofdepression:roleofserotoninandbrainderivedneurotrophicfactor[j].biolpsychiatry,2012,71:30-35.
|
| [5] | stephanpl,jaquenoudsirote,muellerb,etal.adversedrugreactionsfollowingnonresponseinadepressedpatientwithcyp2d6deficiencyandlowcyp3a4/5activity[j].pharmacopsychiatry,2006,39:150-152.
|
| [6] | shamsme,arnethb,hiemkec,etal.cyp2d6polymorphismandclinicaleffectoftheantidepressantvenlafaxine[j].jclinpharmther,2006,31:493-502.
|
| [7] | gonzálezi,peñas-lledóem,pérezb,etal.relationbetweencyp2d6phenotypeandpersonalityinhealthyvolunteers[j].pharmacogenomics,2008,9:833-840.
|
| [8] | breimerdd,schellensjh.a‘cocktail'strategytoassessinvivoox-idativedrugmetabolisminhumans[j].trendspharmcolsci,1990,11:223-225.
|
| [9] | wangd,liupx,zhangzq,etal.simultaneousdeterminationofsixkindsofprobedrugsandrapidevaluationofcyp450isoenzymeactivityinmicebylc-ms/ms[j].bullacadmilmedsci(军事医学科学院院刊),2008,32:545-549.
|
| [10] | duanjj.pharmacokineticsofmethotrexate,5-fluorouracilandcyclophosphamideandcyp450levelandactivityindepressionmodelrats(抑郁大鼠甲氨蝶呤、5-氟尿嘧啶和环磷酰胺药动学及cyp450浓度和活性研究)[d].guangzhou:southernmedicaluniversity,2012.
|
| [11] | slavichgm,o'donovana,epeles,etal.blacksheepgettheblues:apsychobiologicalmodelofsocialrejectionanddepression[j].neuroscibiobehavrev,2010,35:39-45.
|
| [12] | yuehb,mash,chengx.applicationandevaluationofdrug-inducedanimalmodelofdepression[j].intjpsychiatry(国际精神病学杂志),2009,36:33-36.
|
| [13] | willnerp.validity,realiabilityandutilityofthechronicmildstressmodelofdepression:a10-yearreviewandevaluation[j].psychopharmacology(berl),1997,134:319-329.
|
| [14] | duncanle,hutchisonke,careyg,etal.variationinbrain-derivedneurotrophicfactor(bdnf)geneisassociatedwithsymptomsofdepression[j].jaffectdisord,2009,115:215-219.
|
| [15] | brunoniar,lopesm,fregnif.asystemreviewandmeta-analysisofclinicalstudiesonmajordepressionandbdnflevels:implicationfortheroleofneuroplasticityindepression[j].intjneuropsychopharmacol,2008,11:1169-1180.
|
| [16] | katzrj,rothka,carrollbj.acuteandchronicstresseffectsonopenfieldactivityintherat:implicationsforamodelofdepression[j].neuroscibiobehavrev,1981,5:247-251.
|
| [17] | isingrinie,belzungc,freslonjl,etal.fluoxetineeffectonaorticnitricoxide-dependentvasorelaxationintheunpredictablechronicmildstressmodelofdepressioninmice[j].psychosommed,2012,74:63-72.
|
| [18] | zhengxy,gaoxx,liuxj,etal.evaluationofanimalmodelofdepressionbasedonmetabolomictechnology[j].drugevalres(药物评价研究),2010,33:175-179.
|
| [19] | zhub,ou-yangds,chenxp,etal.assessmentofcytochromep450activitybyafive-drugcocktailapproach[j].clinpharmacolther,2001,70:455-461.
|
| [20] | liusj,liuzx,zhoul,etal.impactoftripterygiumactiveingredientonvivoactivityofcyp450inrat[j].chinpharmacolbull(中国药理学通报),2011,27:276-280.
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