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OALib Journal期刊
ISSN: 2333-9721
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p70核糖体蛋白s6激酶抑制剂的研究进展
, PP. 261-271
Keywords: p70核糖体蛋白s6激酶,肿瘤,药效团,构效关系
Abstract:
p70核糖体蛋白s6激酶(p70ribosomalproteins6kinase,p70s6k)是一种多功能的丝氨酸/苏氨酸蛋白激酶,是agc家族的重要成员,在mtor信号通路中起着非常重要的作用。p70s6k与蛋白质的合成、mrna的加工、葡萄糖的体内平衡以及细胞的生长和凋亡等进程密切相关。研究表明,肿瘤的发生与p70s6k的过度激活有关,因此,p70s6k已成为抗癌药物研发的重要潜在靶点之一。本文对p70s6k的生物学功能、作用机制及相关p70s6k抑制剂结构和研究思路做一综述。
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