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OALib Journal期刊
ISSN: 2333-9721
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法尼醇x受体与糖脂代谢
, PP. 245-251
Keywords: 法尼醇x受体,胆汁酸,葡萄糖,脂质,非酒精性脂肪肝
Abstract:
法尼醇x受体(farnesoidxreceptor,fxr)属于核受体超家族,研究证明fxr可调控多种代谢通路,除在胆汁酸代谢中发挥重要作用外,fxr激活后参与维持机体糖脂代谢稳态。随着糖脂代谢异常相关疾病发病率的升高,fxr对糖脂代谢的调节越来越引起研究者的重视。fxr激动剂可能成为治疗2型糖尿病和脂代谢紊乱等代谢性疾病的新型药物靶点。
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