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OALib Journal期刊
ISSN: 2333-9721
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多样性合成及其在药物发现中的应用
, PP. 419-433
Keywords: 多样性合成,多样性,化学空间,化合物库,药物发现
Abstract:
多样性合成旨在高效地构建取代基、官能团、立体化学和骨架多样的化合物库,进而发现多样性的生物学效应.本文结合代表性实例,总结了多样性合成的常见策略,包括基于试剂的策略、基于底物的策略、“构建-耦合-配对”策略以及基于优势结构的多样性合成策略.同时,介绍了通过多样性合成构建的化合物库在药物发现中的应用.
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