|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
齐墩果酸衍生物的合成及抗肿瘤活性研究
, PP. 469-474
Keywords: 齐墩果酸,五环三萜类化合物,抗肿瘤活性
Abstract:
以天然产物齐墩果酸为起始原料,对其c-3位羟基、c-12位双键、c-28位羧基进行结构改造,合成了13个新的齐墩果酸衍生物.目标化合物结构经ms、1hnmr及元素分析确证.采用mtt法,选用高表达人癌细胞(sgc7901、mcf-7和a549)对目标化合物进行初步的体外抗肿瘤活性研究.结果表明,所测化合物对3种肿瘤细胞的抑制活性均明显强于齐墩果酸,其中化合物ii2和ii3对mcf-7和a549细胞表现出很强的抑制活性,明显高于已上市药物吉非替尼,值得进一步研究.
| [1] | zhangsy,liz.progressinoleanolicacidresearch[j].foodfermtech(食品与发酵科技),2010,46:20-24.
|
| [2] | maxh,zhaoyc,yinl,etal.studiesontheeffectofoleanolicacidonexperimentalliverinjury[j].actapharmsin(药学学报),1982,17:93-97.
|
| [3] | tangc,cheny,bais,etal.advancesinthestudyofstructuralmodificationandbiologicalactivitiesofoleanolicacid[j].chinjorgchem(有机化学),2013,33:46-65.
|
| [4] | liud,mengyq,zhaoj.recentadvanceinthestudyonderivativesofoleanolicacidandursolicacid[j].chemistry(化学通报),2007,70:14-20.
|
| [5] | zhaolx,tianmz,jinlj,etal.synthesisandcharacterizationofderivativesofasiaticacidandprimarystudyonanti-canceractivity[j].chinjorgchem(有机化学),2011,31:646-652.
|
| [6] | liwl,chenj,mal,etal.synthesisandevaluationofα-glucosidaseinhibitoryactivityofoleanicacidderivatives[j].chinjmedchem(中国药物化学杂志),2014,24:7-13.
|
| [7] | finlayhj,hondat,gribblegw,etal.novela-ringcleavedanalogsofoleanolicandursolicacidswhichaffectgrowthregulationinnrp152prostatecells[j].bioorgmedchemlett,1997,7:1769-1772.
|
| [8] | kashiwaday,wangh,nagaot,etal.anti-aidsagentsandanti-hivactivityofoleanolicacid,pomolicacid,andstructurallyrelatedtriterpenoids[j].jnatprod,1998,61:1090-1095.
|
| [9] | mengyq,liud,lidd,etal.chemicalmodificationofanantitumoractivityofursolicacidamine.cn,101161670b[p].2011-07-27.
|
| [10] | zhaolx,parkhg,jewss,etal.modificationofc11,c28,c2,3,23orc2,23,28functionalgroupsonasiaticacidandevaluationofhepatoprotectiveeffects[j].bullkoreanchemsoc,2007,28:970-976.
|
| [11] | zhuym,shenjk,wanghk,etal.synthesisandanti-hivactivityofoleanolicacidderivatives[j].bioorgmedchemlett,2001,11:3115-3118.
|
| [12] | shenlh,laiys,zhangyh,etal.synthesisandanti-tumoractivitiesofnitratederivativesofglycyrrhetinicacid[j].jchinpharmuniv(中国药科大学学报),2008,39:103-107.
|
| [13] | mengyq.studiesonchemicalmodificationofboswellicacidsandtheiranti-tumoractivity(乳香酸类化合物的结构改造及其抗癌活性的研究)[d].shenyang:shenyangpharmaceuticaluniversity,2004.
|
| [14] | chenl,shangj,wangzf,etal.synthesisandbiologicalevaluationofnitrate-oleanolicacidhybridsasinhibitorsofhepg2cellapoptosis[j].actapharmsin(药学学报),2010,45:1516-1522.
|
| [15] | mengyq,niehh,wangxc,etal.synthesisandantitumoractivityofoleanolicacidderivatives[j].actapharmsin(药学学报),2011,46:1215-1220.
|
| [16] | mengyq,liud,caill,etal.thesynthesisofursolicacidderivativeswithcytotoxicactivityandtheinvestigationoftheirpreliminarymechanismofaction[j].bioorgmedchem,2009,17:848-854.
|
| [17] | liud,mengyq,zhaoj,etal.synthesisandanti-tumoractivityofnovelamidederivativesofursolicacid[j].chemreschinuniv,2008,24:42-46.
|
| [18] | mengyq,liud,baizw,etal.synthesisandanti-tumoractivityofursolicacidderivatives[j].actapharmsin(药学学报),2011,46:556-560.
|
| [19] | mengyq,xuej,liufx,etal.synthesisandanti-tumoractivityofoleanolicacidderivatives[j].chemistry(化学通报),2013,76:265-269.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
