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OALib Journal期刊
ISSN: 2333-9721
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冰片对大鼠体内cyp2d诱导作用研究
, PP. 459-463
Keywords: 冰片,cyp450,肝微粒体,cyp2d
Abstract:
冰片是传统中药,近年来许多文献报道冰片能提高其他药物的生物利用度,促进其他药物进入血脑屏障,因而冰片与其他药物合用可能产生的药物相互作用受到高度重视,但冰片对肝脏细胞色素p450酶的影响却鲜有报道.本文研究了雄性wistar大鼠连续灌胃冰片一周对大鼠肝脏cyp2d表达与活性以及对cyp2d探针底物右美沙芬大鼠体内药代动力学的影响.结果表明,冰片(33、100和300mg·kg-1·d-1)给药一周对大鼠肝脏cyp2d1mrna和蛋白表达无明显影响,但却显著诱导了cyp2d活性(p<0.05),分别达到1.71、1.97和2.89倍.此外,与对照组相比,冰片(300mg·kg-1·d-1)预给药一周组右美沙芬的达峰浓度cmax降低了10.6%(p>0.05),曲线下面积auc0-∞减少了27.5%(p<0.01),清除率cl/f增大了41.1%(p<0.01),表观分布容积vz/f增大了23.1%(p>0.05),表明冰片预给药一周能明显加速cyp2d探针底物右美沙芬的体内清除.由于冰片对大鼠肝脏cyp2d活性的诱导作用,提示当冰片与cyp2d底物药物共用时,可能存在发生代谢性相互作用的风险.
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