|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
有机阴离子转运多肽活性及表达调控的影响因素
, PP. 400-405
Keywords: 有机阴离子转运多肽,表达,活性,调控
Abstract:
有机阴离子转运多肽(organicaniontransportingpolypeptides,oatp)是一类重要的跨膜摄取转运体,属于溶质转运体(solutecarrier,slc)超家族,以na+和atp非依赖方式参与内源物(胆汁酸、胆红素、前列腺素、甲状腺激素和甾体激素结合物)、药物及毒物转运.多种因素(如激素、炎症因子和药物等)会影响oatp的分布、表达及活性,引起底物在组织器官内蓄积的改变,导致食物-药物及药物-药物相互作用.癌组织内oatp分布特性及表达变化可能参与肿瘤的病理过程.表观基因组学调节与oatp的特异性分布有关.本文就参与oatp表达及功能调控的因素进行综述,为药物研发及发病机制的阐明提供线索.
| [1] | hagenbuchb,meierpj.thesuperfamilyoforganicaniontransportingpolypeptides[j].biochimbiophysacta,2003,1609:1-18.
|
| [2] | hagenbuchb,meierpj.organicaniontransportingpolypeptidesoftheoatp/slc21family:phylogeneticclassificationasoatp/slcosuperfamily,newnomenclatureandmolecular/functionalproperties[j].pflugersarch,2004,447:653-665.
|
| [3] | furihatat,satoht,yamamoton,etal.hepatocytenuclearfactor1alphaisafactorresponsiblefortheinterindividualvariationofoatp1b1mrnalevelsinadultjapaneselivers[j].pharmres,2007,24:2327-2332.
|
| [4] | campbellsd,demoraissm,xujj.inhibitionofhumanorganicaniontransportingpolypeptideoatp1b1asamechanismofdrug-inducedhyperbilirubinemia[j].chembiolinteract,2004,150:179-187.
|
| [5] | chengx,maherj,luh,etal.endocrineregulationofgender-divergentmouseorganicanion-transportingpolypeptide(oatp)expression[j].molpharmacol,2006,70:1291-1297.
|
| [6] | woodm,ananthanarayananm,jonesb,etal.hormonalregulationofhepaticorganicaniontransportingpolypeptides[j].molpharmacol,2005,68:218-225.
|
| [7] | liedauerr,svobodam,wlcekk,etal.differentexpressionpatternsoforganicaniontransportingpolypeptidesinosteosarcomas,bonemetastasesandaneurysmalbonecysts[j].oncolrep,2009,22:1485-1492.
|
| [8] | arakawah,nakanishit,yanagiharac,etal.enhancedexpressionoforganicaniontransportingpolypeptides(oatps)inandrogenreceptor-positiveprostatecancercells:possibleroleofoatp1a2inadaptivecellgrowthunderandrogen-depletedconditions[j].biochempharmacol,2012,84:1070-1077.
|
| [9] | fishercd,lickteigaj,augustinelm,etal.experimentalnon-alcoholicfattyliverdiseaseresultsindecreasedhepaticuptaketransporterexpressionandfunctioninrats[j].eurjpharmacol,2009,613:119-127.
|
| [10] | leveem,lecureurv,stiegerb,etal.regulationofdrugtransporterexpressioninhumanhepatocytesexposedtotheproinflammatorycytokinestumornecrosisfactor-alphaorinterleukin-6[j].drugmetabdispos,2009,37:685-693.
|
| [11] | leveem,jouane,stiegerb,etal.regulationofdrugtransporterexpressionbyoncostatinminhumanhepatocytes[j].biochempharmacol,2011,82:304-311.
|
| [12] | leveem,griponp,stiegerb,etal.down-regulationoforganicaniontransporterexpressioninhumanhepatocytesexposedtotheproinflammatorycytokineinterleukin1beta[j].drugmetabdispos,2008,36:217-222.
|
| [13] | kunzea,huwylerj,camenischg,etal.predictionoforganicanion-transportingpolypeptide1b1-and1b3-mediatedhepaticuptakeofstatinsbasedontransporterproteinexpressionandactivitydata[j].drugmetabdispos,2014,42:1514-1521.
|
| [14] | geiera,dietrichcg,voigts,etal.cytokine-dependentregulationofhepaticorganicaniontransportergenetransactivatorsinmouseliver[j].amjphysiolgastrointestliverphysiol,2005,289:g831-g841.
|
| [15] | tanakay,chenc,maherjm,etal.kupffercell-mediateddownregulationofhepatictransporterexpressioninrathepaticischemia-reperfusion[j].transplantation,2006,82:258-266.
|
| [16] | pichettev,leblondfa.drugmetabolisminchronicrenalfailure[j].currdrugmetab,2003,4:91-103.
|
| [17] | naudj,michaudj,leblondfa,etal.effectsofchronicrenalfailureonliverdrugtransporters[j].drugmetabdispos,2008,36:124-128.
|
| [18] | oguraj,koizumit,segawam,etal.quercetin-3-rhamnoglucoside(rutin)stimulatestransportoforganicanioncompoundsmediatedbyorganicaniontransportingpolypeptide2b1[j].biopharmdrugdispos,2014,35:173-182.
|
| [19] | shirasakay,shichirim,morit,etal.majoractivecomponentsingrapefruit,orange,andapplejuicesresponsibleforoatp2b1-mediateddruginteractions[j].jpharmsci,2013,102:3418-3426.
|
| [20] | rebellos,zhaos,harirys,etal.intestinaloatp1a2inhibitionasapotentialmechanismfortheeffectofgrapefruitjuiceonaliskirenpharmacokineticsinhealthysubjects[j].eurjclinpharmacol,2012,68:697-708.
|
| [21] | dressergk,baileydg,leakebf,etal.fruitjuicesinhibitorganicaniontransportingpolypeptide-mediateddruguptaketodecreasetheoralavailabilityoffexofenadine[j].clinpharmacolther,2002,71:11-20.
|
| [22] | shirasakay,suzukik,nakanishit,etal.differentialeffectofgrapefruitjuiceonintestinalabsorptionofstatinsduetoinhibitionoforganicaniontransportingpolypeptideand/orp-glycoprotein[j].jpharmsci,2011,100:3843-3853.
|
| [23] | shirasakay,kuraokae,spahn-langguthh,etal.speciesdifferenceintheeffectofgrapefruitjuiceonintestinalabsorptionoftalinololbetweenhumanandrat[j].jpharmacolexpther,2010,332:181-189.
|
| [24] | molassiotisa,fernadez-ortegap,pudd,etal.useofcomplementaryandalternativemedicineincancerpatients:aeuropeansurvey[j].annoncol,2005,16:655-663.
|
| [25] | fuchikamih,satohh,tsujimotom,etal.effectsofherbalextractsonthefunctionofhumanorganicanion-transportingpolypeptideoatp-b[j].drugmetabdispos,2006,34:577-582.
|
| [26] | mullerf,frommmf.transporter-mediateddrug-druginteractions[j].pharmacogenomics,2011,12:1017-1037.
|
| [27] | abet,suzukit,unnom,etal.thyroidhormonetransporters:recentadvances[j].trendsendocrinolmetab,2002,13:215-220.
|
| [28] | svobodam,rihaj,wlcekk,etal.organicaniontransportingpolypeptides(oatps):regulationofexpressionandfunction[j].currdrugmetab,2011,12:139-153.
|
| [29] | hagenbuchb,guic.xenobiotictransportersofthehumanorganicaniontransportingpolypeptides(oatp)family[j].xenobiotica,2008,38:778-801.
|
| [30] | lockhartac,harrise,lafleurbj,etal.organicaniontransportingpolypeptide1b3(oatp1b3)isoverexpressedincolorectaltumorsandisapredictorofclinicaloutcome[j].clinexpgastroenterol,2008,1:1-7.
|
| [31] | maherjm,slittal,callaghantn,etal.alterationsintransporterexpressioninliver,kidney,andduodenumaftertargeteddisruptionofthetranscriptionfactorhnf1alpha[j].biochempharmacol,2006,72:512-522.
|
| [32] | khuranav,minocham,pald,etal.roleofoatp-1b1and/oroatp-1b3inhepaticdispositionoftyrosinekinaseinhibitors[j].drugmetabdruginteract,2014,29:179-190.
|
| [33] | sebastiank,detro-dassens,rinisn,etal.characterizationofslco5a1/oatp5a1,asolutecarriertransportproteinwithnon-classicalfunction[j].plosone,2013,8:e83257.
|
| [34] | grubem,kockk,karners,etal.modificationofoatp2b1-mediatedtransportbysteroidhormones[j].molpharmacol,2006,70:1735-1741.
|
| [35] | koenena,kockk,keiserm,etal.steroidhormonesspecificallymodifytheactivityoforganicaniontransportingpolypeptides[j].eurjpharmsci,2012,47:774-780.
|
| [36] | svobodam,wlcekk,tafernerb,etal.expressionoforganicanion-transportingpolypeptides1b1and1b3inovariancancercells:relevanceforpaclitaxeltransport[j].biomedpharmacother,2011,65:417-426.
|
| [37] | manderyk,bujokk,schmidti,etal.influenceoftheflavonoidsapigenin,kaempferol,andquercetinonthefunctionoforganicaniontransportingpolypeptides1a2and2b1[j].biochempharmacol,2010,80:1746-1753.
|
| [38] | qiangf,leebj,leew,etal.pharmacokineticdruginteractionbetweenfexofenadineandfluvastatinmediatedbyorganicanion-transportingpolypeptidesinrats[j].eurjpharmsci,2009,37:413-417.
|
| [39] | bruderers,aanismaap,homerymc,etal.effectofcyclosporineandrifampinonthepharmacokineticsofmacitentan,atissue-targetingdualendothelinreceptorantagonist[j].aapsj,2012,14:68-78.
|
| [40] | zhank,yaoj,huangj,etal.effectofx-rayirradiationonexpressionoforganicaniontransportingpolypeptides[j].intjradiatbiol,2013,89:832-840.
|
| [41] | maedak,sugiyamay.impactofgeneticpolymorphismsoftransportersonthepharmacokinetic,pharmacodynamicandtoxicologicalpropertiesofanionicdrugs[j].drugmetabpharmacokinet,2008,23:223-235.
|
| [42] | nishizatoy,ieirii,suzukih,etal.polymorphismsofoatp-c(slc21a6)andoat3(slc22a8)genes:consequencesforpravastatinpharmacokinetics[j].clinpharmacolther,2003,73:554-565.
|
| [43] | zhanghx,zhaox,yangz,etal.oatp1b1t521c/a388gisanimportantpolymorphismgenerelatedtoneonatalhyperbilirubinemia[j].chinjpediatr(中华儿科杂志),2010,48:650-655.
|
| [44] | nakanishit,tamaii.geneticpolymorphismsofoatptransportersandtheirimpactonintestinalabsorptionandhepaticdispositionofdrugs[j].drugmetabpharmacokinet,2012,27:106-121.
|
| [45] | imais,kikuchir,kusuharah,etal.analysisofdnamethylationandhistonemodificationprofilesofliver-specifictransporters[j].molpharmacol,2009,75:568-576.
|
| [46] | imais,kikuchir,kusuharah,etal.dnamethylationandhistonemodificationprofilesofmouseorganicaniontransportingpolypeptides[j].drugmetabdispos,2013,41:72-78.
|
| [47] | hollavr,backlundmg,yangp,etal.regulationofprostaglandintransportersincolorectalneoplasia[j].cancerprevres,2008,1:93-99.
|
| [48] | ichiharas,kikuchir,kusuharah,etal.dnamethylationprofilesoforganicaniontransportingpolypeptide1b3incancercelllines[j].pharmres,2010,27:510-516.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
