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OALib Journal期刊
ISSN: 2333-9721
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阿尔茨海默病β-淀粉样蛋白的近红外荧光探针研究进展
, PP. 528-534
Keywords: 阿尔茨海默病,β-淀粉样蛋白,近红外荧光探针
Abstract:
阿尔茨海默病(alzheimer'sdisease,ad)是最常见的老年认知障碍疾病。随着社会老龄化越来越严重,ad给患者和社会造成巨大的负担。大脑中aβ-淀粉样蛋白沉积是ad患者早期发现、跟踪、预防和治疗的特异性生物标志物。与正电子发射断层扫描及单光子发射计算机断层显像的核成像相比,近红外荧光成像具有高灵敏度、无创、安全、价廉等优点。因此用于近红外荧光成像的小分子探针成为目前的热点研究领域。本文综述了标记aβ-淀粉样蛋白沉积的近红外荧光小分子探针最新的研究进展。
| [1] | kunghf.theβ-amyloidhypothesisinalzheimer'sdisease:seeingisbelieving[j].acsmedchemlett,2012,3:265-267.
|
| [2] | liurt,lüqj.progressintheresearchonmulti-target-directeddrugsagainstalzheimer'sdisease[j].actapharmsin(药学学报),2009,44:258-263.
|
| [3] | yangwc,sunq,yunx,etal.designofacetylcholinesteraseinhibitorforalzheimer'sdiseasetherapy:frommulti-bindingsiteinhibitorstomulti-targetdirectedligands[j].actapharmsin(药学学报),2012,47:313-321.
|
| [4] | buchhavep,minthonl,zetterbergh,etal.cerebrospinalfluidlevelsofβ-amyloid1-42,butnotoftau,arefullychangedalready5to10yearsbeforetheonsetofalzheimerdementia.[j].archgenpsychiatry,2012,69:98-106.
|
| [5] | selkoedj.translatingcellbiologyintotherapeuticadvancesinalzheimer'sdisease[j].nature,1999,399:a23-a31.
|
| [6] | hardyj,selkoedj.theamyloidhypothesisofalzheimer'sdisease:progressandproblemsontheroadtotherapeutics[j].science,2002,297:353-356.
|
| [7] | ranc,xux,raymondsb,etal.design,synthesis,andtestingofdifluoroboron-derivatizedcurcuminsasnear-infraredprobesforinvivodetectionofamyloid-βdeposits[j].jamchemsoc,2009,131:15257-15261.
|
| [8] | hintersteinerm,enza,freyp,etal.invivodetectionofamyloid-βdepositsbynear-infraredimagingusinganoxazine-derivativeprobe[j].natbiotechnol,2005,23:577-583.
|
| [9] | glennergg,wongcw.alzheimer'sdisease:initialreportofthepurificationandcharacterizationofanovelcerebrovascularamyloidprotein[j].biochembiophysrescommun,1984,120:885-890.
|
| [10] | vallabhajosulas.positronemissiontomographyradiopharmaceuticalsforimagingbrainbeta-amyloid[j].seminnuclmed,2011,41:283-299.
|
| [11] | nesterovee,skochj,hymanbt,etal.invivoopticalimagingofamyloidaggregatesinbrain:designoffluorescentmarkers[j].angewchemintedengl,2005,44:5452-5456.
|
| [12] | kungmp,houc,zhuangzp,etal.bindingoftwopotentialimagingagentstargetingamyloidplaquesinpostmortembraintissuesofpatientswithalzheimer'sdisease[j].brainres,2004,1025:98-105.
|
| [13] | newbergab,winteringna,plösslk,etal.safety,biodistribution,anddosimetryof123i-impy:anovelamyloidplaque-imagingagentforthediagnosisofalzheimer'sdisease[j].jnuclmed,2006,47:748-754.
|
| [14] | zhangw,oyas,kungmp,etal.f-18polyethyleneglycolstilbenesaspetimagingagentstargetingaβaggregatesinthebrain[j].nuclmedbiol,2005,32:799-809.
|
| [15] | agdeppaed,kepev,liuj,etal.bindingcharacteristicsofradiofluorinated6-dialkylamino-2-naphthylethylidenederivativesaspositronemissiontomographyimagingprobesforbeta-amyloidplaquesinalzheimer'sdisease[j].jneurosci,2001,21:rc189.
|
| [16] | gomesa,fernandese,limajl.fluorescenceprobesusedfordetectionofreactiveoxygenspecies[j].jbiochembiophysmethods,2005,65:45-80.
|
| [17] | raoj,dragulescu-andrasia,yaoh.fluorescenceimaginginvivo:recentadvances[j].curropinbiotechnol,2007,18:17-25.
|
| [18] | frangionij.invivonear-infraredfluorescenceimaging[j].curropinbiotechnol,2003,7:626-634.
|
| [19] | tomasellis,espositov,vangonep,etal.theα-to-βconformationaltransitionofalzheimer'saβ-(1-42)peptideinaqueousmediaisreversible:astepbystepconformationalanalysissuggeststhelocationofβconformationseeding[j].chembiochem,2006,7:257-267.
|
| [20] | zhangx,tiany,liz,etal.designandsynthesisofcurcuminanaloguesforinvivofluorescenceimagingandinhibitingcopper-inducedcross-linkingofamyloidbetaspeciesinalzheimer'sdisease[j].jamchemsoc,2013,135:16397-16409.
|
| [21] | klunkwe,bacskaibj,mathisca,etal.imagingaβplaquesinlivingtransgenicmicewithmultiphotonmicroscopyandmethoxy-x04,asystemicallyadministeredcongoredderivative[j].jneuropatholexpneurol,2002,61:797-805.
|
| [22] | liq,leejs,hac,etal.solid-phasesynthesisofstyryldyesandtheirapplicationasamyloidsensors[j].angewchemintedengl,2004,43:6331-6335.
|
| [23] | liq,minj,ahnyh,etal.styryl-basedcompoundsaspotentialinvivoimagingagentsforβ-amyloidplaques[j].chembiochem,2007,8:1679-1687.
|
| [24] | onom,hayashis,kimurah,etal.push-pullbenzothiazolederivativesasprobesfordetectingβ-amyloidplaquesinalzheimer'sbrains[j].bioorgmedchem,2009,17:7002-7007.
|
| [25] | parkyd,parkjh,hurmg,etal.fluorescent2-styrylpyridazin-3(2h)-onederivativesasprobestargetingamyloid-betaplaquesinalzheimer'sdisease[j].bioorgmedchemlett,2012,22:4106-4110.
|
| [26] | nesterovee,skochj,hymanbt,etal.invivoopticalimagingofamyloidaggregatesinbrain:designoffluorescentmarkers[j].angewchemintedengl,2005,44:5452-5456.
|
| [27] | raymondsb,skochj,hillsid,etal.smartopticalprobesfornear-infraredfluorescenceimagingofalzheimer'sdiseasepathology[j].eurjnuclmedmolimaging,2008,35:s93-98.
|
| [28] | onom,ishikawam,kimurah,etal.developmentofdualfunctionalspect/fluorescentprobesforimagingcerebralβ-amyloidplaques[j].bioorgmedchemlett,2010,20:3885-3888.
|
| [29] | onom,watanabeh,kimurah,etal.bodipy-basedmolecularprobeforimagingofcerebralβ-amyloidplaques[j].acschemneurosci,2012,3:319-324.
|
| [30] | okamuran,morim,furumotos,etal.invivodetectionofamyloidplaquesinthemousebrainusingthenear-infraredfluorescenceprobethk-265[j].jalzheimersdis,2011,23:37-48.
|
| [31] | braake,griffingk,araik,etal.neuropathologyofalzheimer'sdisease:whatisnewsincea.alzheimer?[j].eurarchpsychiatryclinneurosci,1999,249:s14-s22.
|
| [32] | gonghc,wangyl,wanghw.epigeneticmechanismsofalzheimer'sdiseaseandrelateddrugresearch[j].actapharmsin(药学学报),2013,48:1005-1013.
|
| [33] | rongxf,wangxl.anoverviewofbiomarkersinalzheimer'sdisease[j].actapharmsin(药学学报),2012,47:551-557.
|
| [34] | shimadzuh,suemotot,suzukim,etal.novelprobesforimagingamyloid-β:f-18andc-11labelingof2-(4-aminostyryl)benzoxazolederivatives[j].jlabelledcompdrad,2004,47:181-190.
|
| [35] | koolem,lewisdm,buckleyc,etal.whole-bodybiodistributionandradiationdosimetryof18f-ge067:aradioligandforinvivobrainamyloidimaging[j].jnuclmed,2009,50:818-822.
|
| [36] | kingwellk.alzheimerdisease:florbetapir-ausefultooltoimageamyloidloadandpredictcognitivedeclineinalzheimerdisease[j].natrevneurol,2012,8:471.
|
| [37] | swahnbm,sandellj,pyringd,etal.synthesisandevaluationofpyridylbenzofuran,pyridylbenzothiazoleandpyridylbenzoxazolederivativesas18f-petimagingagentsforβ-amyloidplaques[j].bioorgmedchemlett,2012,22:4332-4337.
|
| [38] | ntziachristosv,ripollj,wanglv,etal.lookingandlisteningtolight:theevolutionofwhole-bodyphotonicimaging[j].natbiotech,2005,23:313-320.
|
| [39] | ntziachristosv.fluorescencemolecularimaging[j].annurevbiomedeng,2006,8:1-33.
|
| [40] | nesterovee,skochj,hymanbt,etal.invivoopticalimagingofamyloidaggregatesinbrain:designoffluorescentmarkers[j].angewchemintedengl,2005,44:5452-5456.
|
| [41] | zhangs,iwatak,lachenmannmj,etal.thealzheimer'speptideaβadoptsacollapsedcoilstructureinwater[j].jstructbiol,2000,130:130-141.
|
| [42] | changwm,dakanalim,capulecc,etal.anca:afamilyoffluorescentprobesthatbindandstainamyloidplaquesinhumantissue[j].acschemneurosci,2011,2:249-255.
|
| [43] | gemmas,colombol,forlonig,etal.pyrroloquinoxalinehydrazonesasfluorescentprobesforamyloidfibrils[j].orgbiomolchem,2011,9:5137-5148.
|
| [44] | liuk,guotl,chojnackij,etal.bivalentligandcontainingcurcuminandcholesterolasafluorescenceprobeforaβplaquesinalzheimer'sdisease[j].acschemneurosci,2011,3:141-146.
|
| [45] | nilssonkp,aslunda,bergi,etal.imagingdistinctconformationalstatesofamyloid-βfibrilsinalzheimer'sdiseaseusingnovelluminescentprobes[j].acschembiol,2007,2:553-560.
|
| [46] | aslunda,sigurdsoncj,klingstedtt,etal.novelpentamericthiophenederivativesforinvitroandinvivoopticalimagingofaplethoraofproteinaggregatesincerebralamyloidoses[j].acschembiol,2009,4:673-684.
|
| [47] | cuim.pastandrecentprogressofmolecularimagingprobesforβ-amyloidplaquesinthebrain[j].currmedchem,2014,21:82-112.
|
| [48] | cuim,onom,watanabeh,etal.smartnear-infraredfluorescenceprobeswithdonor-acceptorstructureforinvivodetectionofβ-amyloiddeposits[j].jamchemsoc,2014,136:3388-3394.
|
| [49] | hintersteinerm,enza,freyp,etal.invivodetectionofamyloid-βdepositsbynear-infraredimagingusinganoxazine-derivativeprobe[j].natbiotechnol,2005,23:577-583.
|
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