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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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抗hiv药物的最新研究进展
, PP. 509-515
Keywords: 抗逆转录病毒治疗,潜伏感染,hiv治愈
Abstract:
目前多种抗逆转录病毒准新药正在2、3期临床评价中。新的核苷逆转录酶抑制剂tenofoviralafenamide-fumarate(taf)比替诺福韦(tenofovir,tdf)抗病毒活性强且毒性较低;非核苷逆转录酶抑制剂doravirine对该酶耐受病毒株有效,而新的整合酶抑制剂gsk744具有长效的特点。此外,几个具有新的作用机制的化合物也受到关注,如bms-663068小分子化合物是cd4结合的抑制剂,而cenicriviroc是新颖的ccr5/ccr2受体拮抗剂,具有抗hiv和抗炎的双重作用。几类针对潜伏病毒感染的药物也正在研发中,其中组蛋白去乙酰化酶抑制剂发展较快,其余大多处于体外筛选阶段,如蛋白激酶c激活剂、dna甲基转移酶抑制剂、阳性转录延长因子激活剂和组蛋白甲基转移酶抑制剂等。本文对有望近期进入临床使用的新药和可能逆转hiv潜伏感染的化合物进行重点介绍。
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