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OALib Journal期刊
ISSN: 2333-9721
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蛋白及多肽药物干粉吸入剂研究新进展
, PP. 814-823
Keywords: 蛋白质及多肽类药物,干粉吸入剂,载体,肺部沉积率
Abstract:
为成功设计蛋白及多肽类药物物理混合型干粉吸入剂提供理论和实践依据,本文综述和阐明了干粉吸入剂常用载体,药物微粉化制备技术,影响干粉吸入剂肺部沉积的处方工艺因素,包括载体性质、药物载体比例、混合顺序、混合方法和混合时间、药物载体相互作用,以及粉体学性质包括粒径大小和形态、密度、粉体流动性、带电性、分散性、吸湿性对肺部沉积率的影响。依据上述讨论和粉末分散的机制,提出了增加干粉吸入剂肺部沉积率的策略,包括加入载体细粉、加入黏附力控制物质和对药物微粉再加工等。因此,设计肺部沉积率高的蛋白及多肽药物的物理混合型干粉吸入剂需系统地研究药物与载体相互作用,阐明处方工艺及粉体学性质的影响。
| [1] | aguru,ugwokemi,armandm,etal.thelungasarouteforsystemicdeliveryoftherapeuticproteinsandpeptides[j].respirres,2001,2:198-209.
|
| [2] | guilleminaultl,azzopardin,arnoultc,etal.fateofinhaledmonoclonalantibodiesafterthedepositionofaerosolizedparticlesintherespiratorysystem[j].jcontrolrelease,2014,196:344-354.
|
| [3] | razavirohaniss,abnousk,tafaghodim.preparationandcharacterizationofspray-driedpowdersintendedforpulmonarydeliveryofinsulinwithregardtotheselectionofexcipients[j].intjpharm,2014,465:464-478.
|
| [4] | tawfeekhm,evansar,iftikhara,etal.drypowderinhalationofmacromoleculesusingnovelpeg-co-polyestermicroparticlecarriers[j].intjpharm,2013,441:611-619.
|
| [5] | conoled,keatinggm.colistimethatesodiumdrypowderforinhalation:areviewofitsuseinthetreatmentofchronicpseudomonasaeruginosainfectioninpatientswithcysticfibrosis[j].drugs,2014,74:377-387.
|
| [6] | shin,wujh.progressofdrypowderinhalers[j].chinjnewdrugs(中国新药杂志),2007,16:922-925.
|
| [7] | minnea,boireauh,hortamj,etal.optimizationoftheaerosolizationpropertiesofaninhalationdrypowderbasedonselectionofexcipients[j].eurjpharmbiopharm,2008,70:839-844.
|
| [8] | shadbadmrs,millenl,mominm,etal.theeffectofsolventtreatmentontheperformanceofvariouscarriersindrypowderinhalationscontainingsalbutamolsulphate[j].iranjbasicmedsci,2013,16:873-876.
|
| [9] | kaialyw,larhribh,martingp,etal.theeffectofengineeredmannitol-lactosemixtureondrypowderinhalerperformance[j].pharmres,2012,29:2139-2156.
|
| [10] | singhdj,jainrr,sonips,etal.preparationandevaluationofsurfacemodifiedlactoseparticlesforimprovedperformanceoffluticasonepropionatedrypowderinhaler[j].jaerosolmedpulmdrugdeliv,2014,doi:10.1089/jamp.2014.1146.
|
| [11] | dup,duj,smythhdc.evaluationofgranulatedlactoseasacarrierfordpiformulations1:effectofgranulesize[j].aapspharmscitech,2014,15:1417-1428.
|
| [12] | teesk,zengxm,martingp,etal.theuseofdifferentsugarsasfineandcoarsecarriersforaerosolisedsalbutamolsulphate[j].intjpharm,2000,208:111-123.
|
| [13] | kaialyw,nokhodchia.engineeredmannitolternaryadditivesimprovedispersionoflactose-salbutamolsulphatedrypowderinhalations[j].aapsj,2013,15:728-743.
|
| [14] | grasmeijerf,lexmondaj,vandennoortm,etal.newmechanismstoexplaintheeffectsofaddedlactosefinesonthedispersionperformanceofadhesivemixturesforinhalation[j].plosone,2014,9:e87825.
|
| [15] | zengxm,martingp,teesk,etal.effectsofparticlesizeandaddingsequenceoffinelactoseonthedepositionofsalbutamolsulphatefromadrypowderformulation[j].intjpharm,1999,182:133-144.
|
| [16] | jonesmd,pricer.theinfluenceoffineexcipientparticlesontheperformanceofcarrier-baseddrypowderinhalationformulations[j].pharmres,2006,23:1665-1674.
|
| [17] | cordtse,steckelh.capabilitiesandlimitationsofusingpowderrheologyandpermeabilitytopredictdrypowderinhalerperformance[j].eurjpharmbiopharm,2012,82:417-423.
|
| [18] | youngpm,chanhk,chiouh,etal.theinfluenceofmechanicalprocessingofdrypowderinhalercarriersondrugaerosolizationperformance[j].jpharmsci,2007,96:1331-1341.
|
| [19] | loueymd,razias,stewartpj.influenceofphysico-chemicalcarrierpropertiesontheinvitroaerosoldepositionfrominteractivemixtures[j].intjpharm,2003,252:87-98.
|
| [20] | youngpm,edges,trainid,etal.theinfluenceofdoseontheperformanceofdrypowderinhalationsystems[j].intjpharm,2005,296:26-33.
|
| [21] | jonesmd,santojgf,yakubb,etal.therelationshipbetweendrugconcentration,mixingtime,blendingorderandternarydrypowderinhalationperformance[j].intjpharm,2010,391:137-147.
|
| [22] | lucasp,andersonk,staniforthjn.proteindepositionfromdrypowderinhalers:fineparticlemultipletsasperformancemodifiers[j].pharmres,1998,15:562-569.
|
| [23] | alwayb,sangchantrar,stewartpj.modellingthedissolutionofdiazepaminlactoseinteractivemixtures[j].intjpharm,1996,130:213-224.
|
| [24] | loueymd,stewartpj.particleinteractionsinvolvedinaerosoldispersionofternaryinteractivemixtures[j].pharmres,2002,19:1524-1531.
|
| [25] | handokoa,ianl,petersj.influenceofthepolydispersityoftheaddedfinelactoseonthedispersionofsalmeterolxinafoatefrommixturesforinhalation[j].eurjpharmsci,2009,36:265-274.
|
| [26] | youngpm,cocconid,colombop,etal.characterizationofasurfacemodifieddrypowderinhalationcarrierpreparedby"particlesmoothing"[j].jpharmpharmacol,2002,54:1339-1344.
|
| [27] | lohrmannm,kapplm,butthj,etal.adhesionforcesininteractivemixturesfordrypowderinhalers-evaluationofanewmeasuringmethod[j].eurjpharmbiopharm,2007,67:579-586.
|
| [28] | dhandc,prabhakaranmp,beuermanrw,etal.roleofsizeofdrugdeliverycarriersforpulmonaryandintravenousadministrationwithemphasisoncancertherapeuticsandlung-targeteddrugdelivery[j].rscadv,2014,4:32673-32689.
|
| [29] | vanbeverr,mintzesjd,wangj,etal.formulationandphysicalcharacterizationoflargeporousparticlesforinhalation[j].pharmres,1999,16:1735-1742.
|
| [30] | edwardsda,ben-jebriaa,langerr.recentadvancesinpulmonarydrugdeliveryusinglargeporousinhaledparticles[j].japplphysiol,1998,85:379-385.
|
| [31] | nainiv,byronpr,phillipsem.physicochemicalstabilityofcrystallinesugarsandtheirspray-driedforms:dependenceuponrelativehumidityandsuitabilityforuseinpowderinhalers[j].drugdevindpharm,1998,24:895-909.
|
| [32] | servicerf.drugdeliverytakesadeepbreath[j].science,1997,277:1199-1200.
|
| [33] | karhum,kuikkaj,kauppinent,etal.pulmonarydepositionoflactosecarriersusedininhalationpowders[j].intjpharm,2000,1996:95-103.
|
| [34] | thalbergk,berge,franssonm.modelingdispersionofdrypowdersforinhalation.theconceptsoftotalfines,cohesiveenergyandinteractionparameters[j].intjpharm,2012,427:224-233.
|
| [35] | grasmeijerf,frijlinkhw,deboerah.aproposeddefinitionofthe‘activity’ofsurfacesitesonlactosecarriersfordrypowderinhalation[j].eurjpharmsci,2014,56:102-104.
|
| [36] | zhuj,zhangh.fluidizationadditivestofinepowders:us,0009340a1[p].2004-01-15.
|
| [37] | depreterf,pilcerg,amighik.inhaledproteins:challengesandperspectives[j].intjpharm,2013,447:251-280.
|
| [38] | rabbaninr,sevillepc.theinfluenceofformulationcomponentsontheaerosolizationpropertiesofspray-driedpowders[j].jcontrolrelease,2005,110:130-140.
|
| [39] | caow,cheny,zhangzh.applicationoflactoseindrypowderinhaler[j].chinjmodapplpharm(中国现代应用药学),2012,29:591-596.
|
| [40] | islamn,stewartp,larsoni,etal.lactosesurfacemodificationbydecantation:aredrug-finelactoseratiosthekeytobetterdispersionofsalmeterolxinafoatefromlactose-interactivemixtures?[j].pharmres,2004,21:492-499.
|
| [41] | elbaryaa,el-laithyhm,tadrosmi.promisingternarydrypowderinhalerformulationsofcromolynsodium:formulationandinvitro-invivoevaluation[j].archpharmres,2007,30:785-792.
|
| [42] | chenxm.newadvancesofpulmonaydrugdelivey[j].chinjmoddrugapp(中国现代药物应用),2010,4:224-226.
|
| [43] | kobayashis,kondos,junik.pulmonarydeliveryofsalmoncalcitonindrypowderscontainingabsorptionenhancersinrats[j].pharmres,1996,13:80-83.
|
| [44] | tangy,zhujb,chenxj.anovelpulmonarydeliverysystem—drypowderinhalers[j].actapharmsin(药学学报),2009,44:571-574.
|
| [45] | balducciag,cagnanis,sonvicof,etal.pureinsulinhighlyrespirablepowdersforinhalation[j].eurjpharmsci,2014,51:110-117.
|
| [46] | kundank,alfagihim,dennisonsr,etal.bovineserumalbuminadsorbedpga-co-pdlnanocarriersforvaccinedeliveryviadrypowderinhalation[j].pharmres,2015,32:1341-1353.
|
| [47] | healyam,amaromi,paluchkj,etal.drypowdersfororalinhalationfreeoflactosecarrierparticles[j].advdrugdelivrev,2014,75:32-52.
|
| [48] | elverssonj,millqvist-furebya,alderborng,etal.dropletandparticlesizerelationshipandshellthicknessofinhalablelactoseparticlesduringspraydrying[j].jpharmsci,2003,92:900-910.
|
| [49] | bosquillonc,lombryc,préatv,etal.influenceofformulationexcipientsandphysicalcharacteristicsofinhalationdrypowdersontheiraerosolizationperformance[j].jcontrolrelease,2001,70:329-339.
|
| [50] | amidim,pellikaanhc,deboerah,etal.preparationandphysicochemicalcharacterizationofsupercriticallydriedinsulin-loadedmicroparticlesforpulmonarydelivery[j].eurjpharmbiopharm,2008,68:191-200.
|
| [51] | wanghm,futm,guolw.theinfluenceofspraydryingprocessconditionsonphysical,chemicalpropertiesandlunginhalingperformanceofpanaxnotoginsengsaponins-tanshinoneⅱacompositeparticles[j].actapharmsin(药学学报),2013,48:925-932.
|
| [52] | duz,guanyx,yaosj,etal.supercriticalfluidassistedatomizationintroducedbyanenhancedmixerformicronizationoflysozyme:particlemorphology,sizeandproteinstability[j].intjpharm,2011,421:258-268.
|
| [53] | xum,weijy,yubd.advancesofgranulationtechnologyindrypowderinhaler[j].modchinmed(中国现代中药),2012,14:41-44.
|
| [54] | rasenackn,steckelh,müllerbw.micronizationofanti-inflammatorydrugsforpulmonarydeliverybyacontrolledcrystallizationprocess[j].jpharmsci,2003,92:35-44.
|
| [55] | ruchf,matijevi？e.preparationofmicrometersizebudesonideparticlesbyprecipitation[j].jcolloidinterfacesci,2000,229:207-211.
|
| [56] | ógáinon,lijh,tajberl,etal.particleengineeringofmaterialsfororalinhalationbydrypowderinhalers.i-particlesofsugarexcipients(trehaloseandraffinose)forproteindelivery[j].intjpharm,2011,405:23-35.
|
| [57] | zhouq,mortondav.drug-lactosebindingaspectsinadhesivemixtures:controllingperformanceindrypowderinhalerformulationsbyalteringlactosecarriersurfaces[j].advdrugdelivrev,2012,64:275-284.
|
| [58] | wangxb,xirg,yangxb,etal.influenceofformulationexcipientsandphysicalcharacteristicsonlungdepositionofdrypowderinhalations[j].chinjnewdrugs(中国新药杂志),2010,19:580-583.
|
| [59] | johnsonka.preparationofpeptideandproteinpowdersforinhalation[j].advdrugdelivrev,1997,26:3-15.
|
| [60] | pilcerg,wauthozn,amighik.lactosecharacteristicsandthegenerationoftheaerosol[j].advdrugdelivrev,2012,64:233-256.
|
| [61] | trainiad,youngpm,jonesm,etal.comparativestudyoferythritolandlactosemonohydrateascarriersforinhalation:atomicforcemicroscopyandinvitrocorrelation[j].eurjpharmsci,2006,27:243-251.
|
| [62] | endok,amikawas,matsumotoa,etal.erythritol-baseddrypowderofglucagonforpulmonaryadministration[j].intjpharm,2005,290:63-71.
|
| [63] | clelandjl,daughertya,mrsnyr.emergingproteindeliverymethods[j].curropinbiotechnol,2001,12:212-219.
|
| [64] | mominmn,hedayatia,nokhodchia.investigationintoalternativesugarsaspotentialcarriersfordrypowderformulationofbudesonide[j].bioimpacts,2011,1:105-111.
|
| [65] | kaialyw,mominmn,ticehurstmd,etal.engineeredmannitolasanalternativecarriertoenhancedeeplungpenetrationofsalbutamolsulphatefromdrypowderinhaler[j].colloidssurfbbiointerfaces,2010,79:345-356.
|
| [66] | dickhoffbhj,deboerah,lambregtsd,etal.theeffectofcarriersurfacetreatmentondrugparticledetachmentfromcrystallinecarriersinadhesivemixturesforinhalation[j].intjpharm,2006,327:17-25.
|
| [67] | hootonjc,jonesmd,pricer.predictingthebehaviorofnovelsugarcarriersfordrypowderinhalerformulationsviatheuseofacohesive-adhesiveforcebalanceapproach[j].jpharmsci,2006,95:1288-1297.
|
| [68] | levnp,bierendh,robinse,etal.influenceofthelactosegradewithindrypowderformulationsoffluticasonepropionateandterbutalinesulphate[j].intjpharm,2012,422:75-82.
|
| [69] | hindswc.aerosoltechnology:properties,behavior,andmeasurementofairborneparticles[m].newyork:wiley-interscience,1982.
|
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