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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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二甲双胍抗肿瘤机制的研究进展
, PP. 1210-1216
Keywords: 2型糖尿病,二甲双胍,单磷酸腺苷依赖的蛋白激酶,雷帕霉素靶蛋白,胰岛素,胰岛素样生长因子-1,多药耐药
Abstract:
二甲双胍在治疗高血糖与高胰岛素血症方面表现出的有效性、安全性和经济性,使其成为临床上2型糖尿病患者的首选治疗药物。大量的流行病学调查表明,糖尿病不仅与血管病变的发展有关,而且与多种恶性肿瘤的发生密切相关。同时,流行病学与临床观察显示二甲双胍降低多种肿瘤的发病率,改善合并2型糖尿病的肿瘤患者的预后并能提高生存率。此外,二甲双胍已经作为抗肿瘤药物应用于临床试验中。因此,二甲双胍有望成为一个新的肿瘤治疗药物或辅助抗肿瘤药物。本文对二甲双胍抗肿瘤的分子机制进行综述。
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