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OALib Journal期刊
ISSN: 2333-9721
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甘草酸联合利巴韦林体内抗甲型h1n1流感病毒作用
, PP. 966-972
Keywords: 甘草酸,利巴韦林,联合用药,流感病毒,抗病毒作用
Abstract:
利巴韦林具有广谱抗病毒作用,甘草酸具有抗炎、免疫调节和抗病毒活性。为了增强抗病毒药效、减少利巴韦林的不良反应,本文对二者联合应用的抗流感病毒效果进行了研究。以h1n1亚型流感病毒人工感染balb/c小鼠,建立小鼠病毒性肺炎模型。以小鼠存活率、肺指数抑制率和肺病毒滴度等为评价指标,考察甘草酸和利巴韦林联用对感染h1n1亚型流感病毒小鼠的保护作用。结果表明,甘草酸和利巴韦林联用能显著抑制h1n1亚型流感病毒引起的小鼠肺炎实变,对攻毒后第5天小鼠肺指数抑制率为36%;两药联用对感染小鼠有协同保护作用,甘草酸(50mg·kg-1·d-1)与利巴韦林(40mg·kg-1·d-1)联用对感染小鼠的保护率达到100%,显著高于病毒对照组和单一药物组(p<0.01),协同值为36。两药联用显著降低感染小鼠肺组织的病毒滴度(p<0.01),同时对病毒感染诱导的小鼠血浆炎症因子il-6(p<0.01)、tnf-α(p<0.01)和il-1β(p<0.05)的升高具有显著抑制作用。结果提示,甘草酸和利巴韦林联用对感染h1n1亚型流感病毒小鼠具有协同保护作用,在临床上具有重要的应用价值。
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