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OALib Journal期刊
ISSN: 2333-9721
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八角莲内生真菌penicilliumsp.的杂萜和丁内酯类化学成分研究
, PP. 913-920
Keywords: 杂萜,内生真菌,青霉属,异伯克二烯内酯,八角莲
Abstract:
从八角莲内生真菌penicilliumsp.的静息发酵培养物中获得12个化合物，主要包括7个杂萜类化合物。通过现代波谱学鉴定技术分别鉴定为11β-acetoxyisoaustinone（1）、isoberkedienolactone（2）、austin（3）、austinolide（4）、dehydroaustinol（5）、dehydroaustin（6）、chrodrimanina（7）、chrodrimaninb（8）、o-methylmellein（9）、3-（propan-2-ylidene）-pyrrolidine-2，5-dione（10）、（e）-3-[2，5-dioxo-3-（propan-2-ylidene）-pyrrolidin-1-yl]acrylicacid（11）和n-（4-hydroxy-2-methoxyphenyl）-acetamide（12）。杂萜化合物1和丁内酯类化合物2为新化合物。运用gaussian09进行量子化学方法计算化合物2的ecd光谱（tddft/b3lyp/aug-cc-pvdz基组水平），与其ecd实验值曲线具有极佳的拟合，确定了化合物2的绝对立体构型。研究发现，来源于4个或5个乙酰单元的聚酮前体的杂萜类化合物（1，3～8）可以同时存在于同一株野生型青霉属真菌中。同时，化合物经体外细胞毒活性测试，对hct-116、hepg2、bgc-823、nci-h1650和a2780五种细胞系均显示出较弱的生物活性，ic50值大于10μmol·l-1。
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