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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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n-酰基-4-苯基噻唑-2-胺类衍生物的设计、合成及其乙酰胆碱酯酶抑制活性的研究
, PP. 813-818
Keywords: n-酰基-4-苯基噻唑-2-胺,乙酰胆碱酯酶抑制剂,阿尔兹海默症
Abstract:
以α-溴代苯乙酮作为原料，经过3步反应，合成了n-酰基-4-苯基噻唑-2-胺类化合物。采用ellman分光光度法测试了化合物对乙酰胆碱酯酶的体外抑制活性，结果表明，目标化合物具有一定的乙酰胆碱酯酶抑制活性，其中化合物8c的抑制活性最好，其ic50达到了0.51μmol·l-1，优于利斯的明和石杉碱甲。n-酰基-4-苯基噻唑-2-胺对乙酰胆碱酯酶的抑制活性值得进一步研究。
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