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OALib Journal期刊
ISSN: 2333-9721
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罗格列酮对三重转基因小鼠认知障碍的干预作用
, PP. 807-812
Keywords: 罗格列酮,阿尔茨海默病,tau蛋白,神经丝
Abstract:
观察胰岛素增敏剂罗格列酮对3×tg小鼠认知障碍的影响。以雄性c57/bl6小鼠分为正常对照组（wt组）和药物干预组（rsg组），取雄性app/ps1/tau转基因小鼠随机分为模型组（3×tg模型组）和罗格列酮治疗组（3×tg+rsg治疗组）。6月龄小鼠成模后，3×tg+rsg组和rsg组给予罗格列酮（2.5mg·kg-1·d-1）灌胃治疗8周，其他组给予等量生理盐水；选用morris水迷宫实验评估小鼠的认知功能，采用蛋白免疫印迹技术检测小鼠脑内细胞tau蛋白和nfs蛋白磷酸化水平及糖基化水平。结果显示：与wt组和rsg组相比，3×tg模型组的逃避潜伏期和路径长度显著增加，同时明显减少平台所在象限的停留时间和穿越隐匿平台的次数（p<0.05）；此外，模型小鼠脑内tau蛋白和nfs蛋白磷酸化表达水平明显增高而糖基化相关蛋白的表达显著降低（p<0.05）；但3×tg+rsg治疗组在上述行为学和细胞骨架的病理学改变方面有明显的改善（p<0.05）。结果提示：罗格列酮可以改善3×tg模型小鼠阿尔茨海默病（ad）样的学习记忆减退和tau蛋白的过磷酸化表达。
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