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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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索拉非尼类似物的合成和体外抗肿瘤活性研究
, PP. 639-643
Keywords: 索拉非尼,抗肿瘤活性,构效关系
Abstract:
本研究以索拉非尼为先导化合物，对其结构进行改造，合成了一系列酰肼羧酸类化合物。用mtt法对目标化合物进行了体外抗肿瘤活性筛选，结果显示部分化合物对测试肿瘤细胞的抑制活性优于阳性对照药索拉非尼，其中化合物7c对achn、hct116、mda-mb-231的ic50值分别为9.01、4.97和6.61μmol·l-1。
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