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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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基于药代动力学参数分析比较葛根芩连汤的不同配伍肠吸收特性
, PP. 1611-1617
Keywords: 中药复方,药代动力学,葛根芩连汤,配伍,肠吸收
Abstract:
基于药代动力学参数分析比较葛根芩连汤不同配伍组中葛根素、黄芩苷、小檗碱和甘草苷的肠吸收差异。葛根芩连汤中4种药效成分的浓度应用lc-ms/ms方法进行测定,血药浓度-时间数据利用das软件进行动力学分析,并结合大鼠肠外翻及在体单向肠道灌流实验数据,比较不同配伍方式下4种成分的吸收差异。结果显示全方组中葛根素、黄芩苷及小檗碱auc值显著提高,甘草苷auc值显著降低,而肠外翻及在体单向肠道灌流的实验结果表明4种成分在全方组吸收明显提高,说明全方配伍可促进4种成分肠道吸收,但同时其可能加快了肝药酶对甘草苷的代谢。
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