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OALib Journal期刊
ISSN: 2333-9721
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基于中药醒鼻方的丹冰自微乳化给药系统的制备
, PP. 1602-1610
Keywords: 自微乳化给药系统,丹皮酚,冰片,三元相图
Abstract:
本文制备了丹皮酚(paeonol,pae)和冰片(borneol,bor)混合物的自微乳化给药系统(self-microe-mulsifyingdrugdeliverysystem,smedds)。通过测定溶解度、三元相图法和单纯形网格法筛选和优化其处方,制备丹冰smedds,测定其形成微乳后的粒径,采用透射电子显微镜(transmissionelectronmicroscopy,tem)观察其形态,并用气相色谱法测定其中pae和bor的含量。结果显示,以油酸乙酯(ethyloleate,eo)为油相,聚氧乙烯蓖麻油(cremophorel35,el35)为表面活性剂,二乙二醇单乙基醚(transcutolhp,hp)为助表面活性剂时,能形成微乳的区域大于其他组合;当其比例为20:45:35,微乳液粒径(particlediameter,pd)在34nm左右,多分散指数(polydispersityindex,pi)在0.2左右。最终所制得的丹冰smedds中含pae16%、bor2%、eo16%、el3537%和hp29%。丹冰smedds的制备工艺简单、性质稳定,为相关中药和相关成分的研究提供参考。
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