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OALib Journal期刊
ISSN: 2333-9721
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微量量热法体外表征拉米夫定对肠道特征菌群的影响
, PP. 1590-1594
Keywords: 拉米夫定,肠道菌群,微生态平衡,微量量热法
Abstract:
采用微量量热法研究拉米夫定对3种肠道特征细菌青春双歧杆菌、痢疾志贺菌及大肠埃希菌生长代谢的影响。在不同给药剂量下,以表达功率-时间曲线(热谱曲线)的特征参数生长速率常数(k)、热功率(p)、达峰时间(t)、发热量(q)为指标,对拉米夫定影响肠道特征细菌生长代谢程度进行客观地量化评价。结果显示,拉米夫定对青春双歧杆菌的半数抑制率(ic50)为200μgsml-1,对痢疾志贺菌的ic50大于3000μgsml-1,对大肠埃希菌的ic50大于6000μgsml-1。结果显示,拉米夫定对3种肠道特征菌群抑制效果呈现明显差异,其“敏感”程度依次为青春双歧杆菌>痢疾志贺菌>大肠埃希菌;研究提示长期口服拉夫米定可能破坏菌道菌群平衡,存在导致内毒素等增加、引发炎症、加速肝病病情恶化的潜在风险。
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