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药学学报  2013 

肠道细菌对柚皮苷的代谢研究

, PP. 1817-1822

Keywords: 柚皮苷,肠道细菌,uplc-q-tof/ms,代谢产物,16srrna

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Abstract:

研究人体肠道细菌对柚皮苷的代谢。采集健康志愿者新鲜粪便,称重稀释后厌氧培养,通过反复涂布分离得到69种人体肠道细菌。采用uplc-q-tof/ms研究柚皮苷经粪便混合菌及分离的单菌作用后的代谢产物,共鉴定出乙酰化结合产物、苷元及氢化的苷元3种代谢产物;其中对柚皮苷有特殊代谢活性的4种单菌采用16srrna进行了鉴定,分别为enterococcussp.30、bacillussp.46、escherichiasp.54和escherichiasp.63。结果显示肠道细菌对柚皮苷有代谢作用且由不同细菌完成。

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