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药学学报  2014 

基于多元回归分析干法制粒工艺参数与颗粒质量的相关性

, PP. 406-410

Keywords: 干法制粒,工艺参数,多元回归分析,数学模型,相关性

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Abstract:

本文以微晶纤维素wj101为模型物料,通过单因素考察各个工艺参数对干法制粒后颗粒得率和脆碎度的影响,再综合考察工艺参数对颗粒得率和脆碎度的影响,建立工艺参数和颗粒质量的相关性。利用多元线性回归分析得到工艺参数与颗粒得率、脆碎度之间的回归方程,并得到工艺参数对颗粒得率和脆碎度影响大小的顺序:滚轮转速>滚轮压力>水平送料速度。颗粒得率与滚轮压力、水平送料速度呈正相关性,与滚轮转速呈负相关;颗粒的脆碎度与之相反。对比模型模拟结果和实际结果,两者无显著性差异(p>0.05),说明模型具有较高的预测精度及可信度。

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