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OALib Journal期刊
ISSN: 2333-9721
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千里光对小鼠体外培养胚胎的胚胎毒性研究
, PP. 1267-1272
Keywords: 千里光,千里光菲灵碱,克氏千里光碱,千里光碱,全胚胎培养,胚胎毒性
Abstract:
为了探讨千里光的胚胎发育毒性，采用小鼠全胚胎培养模型，将8.5天小鼠胚胎从母体分离后，在含有千里光单体成分千里光菲灵碱和克氏千里光碱的即刻离心血清中培养48h（千里光菲灵碱的终质量浓度分别为12.5、25、50和100μg·ml-1，克氏千里光碱的终质量浓度分别为12.5、25和50μg·ml-1），观察千里光菲灵碱和克氏千里光碱对胚胎生长发育和组织器官形态分化的影响。结果表明，千里光菲灵碱和克氏千里光碱对胚胎的生长发育和形态分化均具有毒性影响，其毒性具有一定的剂量相关性。千里光所含生物碱成分对体外培养的小鼠胚胎有明显的毒性作用，提示妊娠期暴露于千里光对胎儿具有潜在的毒性。
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